Evaluating the human relevance of chemically induced animal tumors

Samuel Monroe Cohen, James Klaunig, M. Elizabeth Meek, Richard N. Hill, Timothy Pastoor, Lois Lehman-McKeeman, John Bucher, David G. Longfellow, Jennifer Seed, Vicki Dellarco, Penelope Fenner-Crisp, Dorothy Patton

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Defining the mode(s) of action by which chemicals induce tumors in laboratory animals has become a key to judgments about the relevance of such tumor data for human risk assessment. Frameworks for analyzing mode of action information appear in recent U.S. EPA and IPCS publications relating to cancer risk assessment. This FORUM paper emphasizes that mode of action analytical frameworks depend on both qualitative and quantitative evaluations of relevant data and information: (1) presenting key events in the animal mode of action, (2) developing a "concordance" table for side-by-side comparison of key events as defined in animal studies with comparable information from human systems, and (3) using data and information from mode of action analyses, as well as information on relative sensitivity and exposure, to make weight-of-evidence judgments about the relevance of animal tumors for human cancer assessments. The paper features a systematic analysis for using mode of action information from animal and human studies, based in part on case examples involving environmental chemicals and pharmaceuticals.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalToxicological Sciences
Volume78
Issue number2
DOIs
StatePublished - Apr 1 2004

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Tumors
Animals
Neoplasms
Risk assessment
Pharmacologic Actions
Laboratory Animals
Information Systems
Publications
Weights and Measures
Pharmaceutical Preparations

Keywords

  • Carcinogenic mode of action
  • Human relevance of animal tumors
  • PPARα agonists
  • Risk assessment

ASJC Scopus subject areas

  • Toxicology

Cite this

Cohen, S. M., Klaunig, J., Meek, M. E., Hill, R. N., Pastoor, T., Lehman-McKeeman, L., ... Patton, D. (2004). Evaluating the human relevance of chemically induced animal tumors. Toxicological Sciences, 78(2), 181-186. https://doi.org/10.1093/toxsci/kfh073

Evaluating the human relevance of chemically induced animal tumors. / Cohen, Samuel Monroe; Klaunig, James; Meek, M. Elizabeth; Hill, Richard N.; Pastoor, Timothy; Lehman-McKeeman, Lois; Bucher, John; Longfellow, David G.; Seed, Jennifer; Dellarco, Vicki; Fenner-Crisp, Penelope; Patton, Dorothy.

In: Toxicological Sciences, Vol. 78, No. 2, 01.04.2004, p. 181-186.

Research output: Contribution to journalArticle

Cohen, SM, Klaunig, J, Meek, ME, Hill, RN, Pastoor, T, Lehman-McKeeman, L, Bucher, J, Longfellow, DG, Seed, J, Dellarco, V, Fenner-Crisp, P & Patton, D 2004, 'Evaluating the human relevance of chemically induced animal tumors', Toxicological Sciences, vol. 78, no. 2, pp. 181-186. https://doi.org/10.1093/toxsci/kfh073
Cohen SM, Klaunig J, Meek ME, Hill RN, Pastoor T, Lehman-McKeeman L et al. Evaluating the human relevance of chemically induced animal tumors. Toxicological Sciences. 2004 Apr 1;78(2):181-186. https://doi.org/10.1093/toxsci/kfh073
Cohen, Samuel Monroe ; Klaunig, James ; Meek, M. Elizabeth ; Hill, Richard N. ; Pastoor, Timothy ; Lehman-McKeeman, Lois ; Bucher, John ; Longfellow, David G. ; Seed, Jennifer ; Dellarco, Vicki ; Fenner-Crisp, Penelope ; Patton, Dorothy. / Evaluating the human relevance of chemically induced animal tumors. In: Toxicological Sciences. 2004 ; Vol. 78, No. 2. pp. 181-186.
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