Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy

Eric S. Peeples, Chikodinaka K. Ezeokeke, Sandra E. Juul, Pierre D. Mourad

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: To compare ultrasound-derived resistive indices (RIs) obtained at the level of the thalamus via fast Doppler ultrasound with traditional anterior cerebral artery measures in a model of neonatal hypoxic-ischemic encephalopathy and to correlate each with clinical outcomes. Methods: Nine nonhuman primate neonates underwent no umbilical cord occlusion (n = 3), umbilical cord occlusion without hypothermia (n = 3), or umbilical cord occlusion with hypothermia (n = 3). The RI was measured in the anterior cerebral artery and thalamus on days 0, 1, and 4 of life. Magnetic resonance imaging with spectroscopy was performed on day 4. Results: Mean thalamus and anterior cerebral artery RI values in the first 36 hours of life were statistically different in neonates who died (+0.13; P =.019) or developed cerebral palsy (−0.08; P =.003). Thalamic RI values showed stronger associations with serum and spectroscopic lactate values than those in the anterior cerebral artery. The umbilical cord occlusion-with-hypothermia group showed a significant increase in the RI in the thalamus but not the anterior cerebral artery. Conclusions: Resistive index measurements in the thalamus may eventually supplement other bedside measures for predicting outcomes in the HIE population, but further studies need to differentiate the effect of hypothermia from illness severity on thalamic perfusion.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume37
Issue number4
DOIs
StatePublished - Apr 2018

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Brain Hypoxia-Ischemia
Anterior Cerebral Artery
Primates
Umbilical Cord
Hypothermia
Thalamus
Perfusion
Anterior Thalamic Nuclei
Doppler Ultrasonography
Cerebral Palsy
Lactic Acid
Spectrum Analysis
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Serum
Population

Keywords

  • animal studies
  • fast Doppler
  • neonate
  • neurosonology (pediatric)
  • resistive index
  • ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy. / Peeples, Eric S.; Ezeokeke, Chikodinaka K.; Juul, Sandra E.; Mourad, Pierre D.

In: Journal of Ultrasound in Medicine, Vol. 37, No. 4, 04.2018, p. 913-920.

Research output: Contribution to journalArticle

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