Eukaryotic transcriptional regulatory complexes: Cooperativity from near and afar

Kazuhiro Ogata, Ko Sato, Tahir Tahirov

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFβ-DNA, NFAT-Fos-Jun-DNA, GABPα-GABPβ-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPβ-DNA complex), and their regulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2003

Fingerprint

DNA
Proteins
Genes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Cite this

Eukaryotic transcriptional regulatory complexes : Cooperativity from near and afar. / Ogata, Kazuhiro; Sato, Ko; Tahirov, Tahir.

In: Current Opinion in Structural Biology, Vol. 13, No. 1, 01.02.2003, p. 40-48.

Research output: Contribution to journalReview article

@article{5d1eeeb22d3241d9a2ce74de9fc4ee21,
title = "Eukaryotic transcriptional regulatory complexes: Cooperativity from near and afar",
abstract = "It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFβ-DNA, NFAT-Fos-Jun-DNA, GABPα-GABPβ-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPβ-DNA complex), and their regulatory mechanisms.",
author = "Kazuhiro Ogata and Ko Sato and Tahir Tahirov",
year = "2003",
month = "2",
day = "1",
doi = "10.1016/S0959-440X(03)00012-5",
language = "English (US)",
volume = "13",
pages = "40--48",
journal = "Current Opinion in Structural Biology",
issn = "0959-440X",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Eukaryotic transcriptional regulatory complexes

T2 - Cooperativity from near and afar

AU - Ogata, Kazuhiro

AU - Sato, Ko

AU - Tahirov, Tahir

PY - 2003/2/1

Y1 - 2003/2/1

N2 - It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFβ-DNA, NFAT-Fos-Jun-DNA, GABPα-GABPβ-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPβ-DNA complex), and their regulatory mechanisms.

AB - It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFβ-DNA, NFAT-Fos-Jun-DNA, GABPα-GABPβ-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPβ-DNA complex), and their regulatory mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=0037311664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037311664&partnerID=8YFLogxK

U2 - 10.1016/S0959-440X(03)00012-5

DO - 10.1016/S0959-440X(03)00012-5

M3 - Review article

C2 - 12581658

AN - SCOPUS:0037311664

VL - 13

SP - 40

EP - 48

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

IS - 1

ER -