ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells

Erika I. Boesen, Karthik R. Krishnan, Jennifer S. Pollock, David M. Pollock

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

T cells and endothelin (ET-1) both contribute to angiotensin II (AngII)-dependent hypertension. To determine whether ET-1, via the ET A receptor, facilitates T cell infiltration in the kidney during AngII-dependent hypertension, we measured T cell infiltration in response to four different treatments: saline, AngII infusion, AngII infusion with an ETA receptor antagonist, or AngII infusion with triple- antihypertensive therapy. After 14 days, AngII increased both BP and the numbers of CD3+and proliferating cells in the kidney. Mice treated concomitantly with the ETAreceptor antagonist had lower BP and fewer CD3+ and proliferating cells in the renal cortex. Mice treated with triple therapy had similar reductions in BP but no change in renal cortical CD3+ cells compared with kidneys from AngII-infused hypertensive mice. In the outer medulla, both the ETA receptor antagonist and triple therapy reduced the number of CD3+ cells and macrophages. Taken together, these data suggest that ETA receptor activation in AngII-mediated hypertension increases CD3+ cells and proliferation in the renal cortex independent of changes in BP, but changes in the number of inflammatory cells in the renal medulla are BP dependent.

Original languageEnglish (US)
Pages (from-to)2187-2192
Number of pages6
JournalJournal of the American Society of Nephrology
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2011

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Angiotensin II
T-Lymphocytes
Kidney
Hypertension
Cell Count
Angiotensin Receptor Antagonists
Endothelin-1
T-Cell Antigen Receptor
Antihypertensive Agents
Therapeutics
Macrophages
Cell Proliferation

ASJC Scopus subject areas

  • Nephrology

Cite this

ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells. / Boesen, Erika I.; Krishnan, Karthik R.; Pollock, Jennifer S.; Pollock, David M.

In: Journal of the American Society of Nephrology, Vol. 22, No. 12, 01.12.2011, p. 2187-2192.

Research output: Contribution to journalArticle

Boesen, Erika I. ; Krishnan, Karthik R. ; Pollock, Jennifer S. ; Pollock, David M. / ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells. In: Journal of the American Society of Nephrology. 2011 ; Vol. 22, No. 12. pp. 2187-2192.
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