Estrogen receptor alpha promotes lupus in (NZB × NZW)F1 mice in a B cell intrinsic manner

Dana E. Tabor, Karen A Gould

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Lupus is a systemic autoimmune disease characterized by the production of autoreactive antibodies against nuclear antigens. Women are disproportionately affected by lupus, and this sex bias is thought to be due, in large part, to the ability of estrogens to promote lupus pathogenesis. Previously, we have shown that global deletion of estrogen receptor alpha (ERα) significantly attenuated loss of tolerance, immune cell activation, autoantibody production, and the development of lupus nephritis. Here we show that targeted deletion of ERα specifically in B cells retards production of pathogenic autoantibodies and the development of nephritis in lupus-prone (NZB × NZW)F1 mice. Furthermore, we observed that ERα deletion in B cells was associated with decreased B cell activation in young, pre-autoimmune (NZB × NZW)F1 females. Altogether, these data suggest that ERα acts in a B cell-intrinsic manner to control B cell activation, autoantibody production, and lupus nephritis.

Original languageEnglish (US)
Pages (from-to)41-52
Number of pages12
JournalClinical Immunology
Volume174
DOIs
StatePublished - Jan 1 2017

Fingerprint

Estrogen Receptor alpha
B-Lymphocytes
Lupus Nephritis
Autoantibodies
Sexism
Nuclear Antigens
Immune Tolerance
Aptitude
Autoimmune Diseases
Antibody Formation
Estrogens

Keywords

  • B cell
  • Estrogen receptor alpha
  • Immune cell activation
  • Immunologic tolerance
  • Lupus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Estrogen receptor alpha promotes lupus in (NZB × NZW)F1 mice in a B cell intrinsic manner. / Tabor, Dana E.; Gould, Karen A.

In: Clinical Immunology, Vol. 174, 01.01.2017, p. 41-52.

Research output: Contribution to journalArticle

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