Estriol therapy of metastatic breast cancer

H. M. Lemon, J. F. Foley, Margaret Anne Kessinger

Research output: Contribution to journalArticle

Abstract

Reduced estriol (E3)/estrone + estradiol 17B excretion is present in Caucasians as compared to Asiatics, and Caucasian women with chronic cystic disease or untreated breast carcinoma are 3 times as likely as controls to excrete subnormal estriol quotients. E3 20 to 30 mcg/Kg/day specifically prevents 90% of chemically induced breast carcinoma during the natural life span of intact female rats (p<.001), probably by displacement of estradiol from breast estrophile proteins. None of 18 other steroids was as effective at this dosage. To evaluate feasibility of chronic E3 therapy, 2.5 to 5.0 mg daily were fed once daily to 18+ breast cancer patients aged 51 to 74. Median vaginal cornified cells increased from 2% to 21% with endometrial bleeding in 3. Minimal increase in serum total lipids and in triglyceride fraction was noted in 3/5 patients. Increased bone pain from osseous lesions stopped therapy in 3 patients. No nausea, hypertension, edema or weight gains occurred. Clinical arrest of lung, bone or skin metastases without new lesions was noted in 3 patients treated for 2.5 to 11.0 mth. More than 25% reduction in 2 diameters of skin metastases without new lesions was noted in 3 additional patients lasting 5 to 10 mth. The feasibility and safety of chronic oral E3 therapy in women has been demonstrated.

Original languageEnglish (US)
JournalProceedings of the American Association for Cancer Research
Volume16
Issue number66
StatePublished - Jan 1 1975

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Estriol
Breast Neoplasms
Estradiol
Neoplasm Metastasis
Therapeutics
Bone and Bones
Skin
Estrone
Nausea
Weight Gain
Edema
Triglycerides
Breast
Chronic Disease
Steroids
Hemorrhage
Hypertension
Lipids
Safety
Pain

ASJC Scopus subject areas

  • Medicine(all)

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Estriol therapy of metastatic breast cancer. / Lemon, H. M.; Foley, J. F.; Kessinger, Margaret Anne.

In: Proceedings of the American Association for Cancer Research, Vol. 16, No. 66, 01.01.1975.

Research output: Contribution to journalArticle

Lemon, H. M. ; Foley, J. F. ; Kessinger, Margaret Anne. / Estriol therapy of metastatic breast cancer. In: Proceedings of the American Association for Cancer Research. 1975 ; Vol. 16, No. 66.
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