Estimation of the basic reproduction ratio (R0) for Shiga toxin-producing Escherichia coli O157:H7 (STEC O157) in beef calves

W. W. Laegreid, James Keen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To understand the dynamics of transmission of Shiga toxin-producing Escherichia coli O157:H7 (STEC O157) in beef calves, serum samples were obtained from calves in a beef cow-calf herd approximately every 6 weeks from birth until weaning for three consecutive years. The presence of specific anti-O157 antibodies in these serum samples was detected using a blocking ELISA assay incorporating an anti-O157 monoclonal antibody. Using seroconversion data, the basic reproduction ratio (R0) was estimated for each of the three years as well as in aggregate using both deterministic and Martingale methods. R0 for STEC O157 infection in range beef calves by deterministic methods varied from 2.9-5.6, with an average of 4.3 (95% CI 2.8-5.9). Martingale estimates of R0 ranged from 3.5-7.4, or 5.3 (95% CI 3.9-6.6), for data from all three years. Given the above estimate of R0, it is predicted that 65-86% of a herd of calves must be effectively vaccinated, or must be rendered non-susceptible through other means, to eliminate STEC O157 infection from a herd.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalEpidemiology and Infection
Volume132
Issue number2
DOIs
StatePublished - Apr 1 2004

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Basic Reproduction Number
Shiga-Toxigenic Escherichia coli
Escherichia coli O157
Infection
Weaning
Serum
Anti-Idiotypic Antibodies
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
Parturition
Red Meat

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

Cite this

Estimation of the basic reproduction ratio (R0) for Shiga toxin-producing Escherichia coli O157:H7 (STEC O157) in beef calves. / Laegreid, W. W.; Keen, James.

In: Epidemiology and Infection, Vol. 132, No. 2, 01.04.2004, p. 291-295.

Research output: Contribution to journalArticle

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