Estimation of in vivo aminoacylation by periodate oxidation: tRNA alterations and iodate inhibition

Arnold A. Rizzino, Martin Freundlich

Research output: Contribution to journalArticle

8 Scopus citations


Two problems associated with periodate oxidation in determining the extent of aminoacylation of tRNA are discussed. One of the products of this reaction, sodium iodate, was found to inhibit tRNA charging. In addition, periodate oxidation also appears to alter sites other than the 3′-end on at least two isoacceptor species of tRNALeu.

Original languageEnglish (US)
Pages (from-to)446-449
Number of pages4
JournalAnalytical Biochemistry
Issue number2
StatePublished - Jun 1975


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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