ESCRT proteins: Double-edged regulators of cellular signaling

Chun Tu, Gulzar Ahmad, Bhopal Mohapatra, Sohinee Bhattacharyya, Cesar F. Ortega-Cava, Byung Min Chung, Kay Uwe Wagner, Srikumar M. Raja, Mayumi Naramura, Vimla Band, Hamid Band

Research output: Contribution to journalComment/debate

11 Citations (Scopus)

Abstract

ESCRT pathway proteins play a key role in sorting ubiquitinated membrane receptors towards lysosomes providing an important mechanism for attenuating cell surface receptor signaling. However, recent studies point to a positive role of ESCRT proteins in signal transduction in multiple species studied under physiological and pathological conditions. ESCRT components such as Tsg101 and Hrs are overexpressed in human cancers and Tsg101 depletion is detrimental for cell proliferation, survival and transformed phenotype of tumor cells. However, the mechanisms underlying the positive contributions of ESCRT pathway to surface receptor signaling have remained unclear. In a recent study, we showed that Tsg101 and Vps4 are essential for translocation of active Src from endosomes to focal adhesion and invadopodia, thereby revealing a role of ESCRT pathway in promoting Src-mediated migration and invasion. We discuss the implications of these and other recent studies which together suggest a role for the ESCRT pathway in recycling of endocytic cargo proteins, aside from its role in lysosomal targeting, potentially explaining the positive roles of ESCRT proteins in signal transduction.

Original languageEnglish (US)
Pages (from-to)45-48
Number of pages4
JournalBioArchitecture
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Signal Transduction
Proteins
Focal Adhesions
Endosomes
Recycling
Cell Surface Receptors
Lysosomes
Neoplasms
Cell Survival
Cell Proliferation
Phenotype
Membranes
Podosomes

Keywords

  • Cancer
  • ESCRT proteins
  • Endocytotic trafficking
  • Lysosomal degradation
  • Receptor tyrosine kinase
  • Recycling
  • Signal transduction
  • Src

ASJC Scopus subject areas

  • Structural Biology
  • Cell Biology

Cite this

Tu, C., Ahmad, G., Mohapatra, B., Bhattacharyya, S., Ortega-Cava, C. F., Chung, B. M., ... Band, H. (2011). ESCRT proteins: Double-edged regulators of cellular signaling. BioArchitecture, 1(1), 45-48. https://doi.org/10.4161/bioa.1.1.15173

ESCRT proteins : Double-edged regulators of cellular signaling. / Tu, Chun; Ahmad, Gulzar; Mohapatra, Bhopal; Bhattacharyya, Sohinee; Ortega-Cava, Cesar F.; Chung, Byung Min; Wagner, Kay Uwe; Raja, Srikumar M.; Naramura, Mayumi; Band, Vimla; Band, Hamid.

In: BioArchitecture, Vol. 1, No. 1, 01.01.2011, p. 45-48.

Research output: Contribution to journalComment/debate

Tu, C, Ahmad, G, Mohapatra, B, Bhattacharyya, S, Ortega-Cava, CF, Chung, BM, Wagner, KU, Raja, SM, Naramura, M, Band, V & Band, H 2011, 'ESCRT proteins: Double-edged regulators of cellular signaling', BioArchitecture, vol. 1, no. 1, pp. 45-48. https://doi.org/10.4161/bioa.1.1.15173
Tu C, Ahmad G, Mohapatra B, Bhattacharyya S, Ortega-Cava CF, Chung BM et al. ESCRT proteins: Double-edged regulators of cellular signaling. BioArchitecture. 2011 Jan 1;1(1):45-48. https://doi.org/10.4161/bioa.1.1.15173
Tu, Chun ; Ahmad, Gulzar ; Mohapatra, Bhopal ; Bhattacharyya, Sohinee ; Ortega-Cava, Cesar F. ; Chung, Byung Min ; Wagner, Kay Uwe ; Raja, Srikumar M. ; Naramura, Mayumi ; Band, Vimla ; Band, Hamid. / ESCRT proteins : Double-edged regulators of cellular signaling. In: BioArchitecture. 2011 ; Vol. 1, No. 1. pp. 45-48.
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