Ergodic Sets as Cell Phenotype of Budding Yeast Cell Cycle

Robert G. Todd, Tomas Helikar

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It has been suggested that irreducible sets of states in Probabilistic Boolean Networks correspond to cellular phenotype. In this study, we identify such sets of states for each phase of the budding yeast cell cycle. We find that these "ergodic sets" underly the cyclin activity levels during each phase of the cell cycle. Our results compare to the observations made in several laboratory experiments as well as the results of differential equation models. Dynamical studies of this model: (i) indicate that under stochastic external signals the continuous oscillating waves of cyclin activity and the opposing waves of CKIs emerge from the logic of a Boolean-based regulatory network without the need for specific biochemical/kinetic parameters; (ii) suggest that the yeast cell cycle network is robust to the varying behavior of cell size (e.g., cell division under nitrogen deprived conditions); (iii) suggest the irreversibility of the Start signal is a function of logic of the G1 regulon, and changing the structure of the regulatory network can render start reversible.

Original languageEnglish (US)
Article numbere45780
JournalPloS one
Volume7
Issue number10
DOIs
StatePublished - Oct 1 2012

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Saccharomycetales
Yeast
cell cycle
Cell Cycle
Cyclins
Cells
cyclins
yeasts
Phenotype
phenotype
Regulon
regulon
cells
Cell Size
Cell Division
cell division
Nitrogen
Yeasts
kinetics
Kinetic parameters

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ergodic Sets as Cell Phenotype of Budding Yeast Cell Cycle. / Todd, Robert G.; Helikar, Tomas.

In: PloS one, Vol. 7, No. 10, e45780, 01.10.2012.

Research output: Contribution to journalArticle

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