Epstein-Barr Virus Infection and Antibody Synthesis in Patients With Multiple Sclerosis

Patrick F. Bray, Linda C. Bloomer, V. C. Salmon, Mark H. Bagley, Paul D. Larsen

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

We studied infectious and immune mechanisms in demyelinating disease. The clinical diagnosis in this study of 313 consecutive cases of multiple sclerosis (MS) was based on the clinical conclusions of two or more neurologists and definite abnormalities in CSF lgG. Measurement of antibodies to six microbial agents was compared in 313 patients with MS and 406 controls in the same age range. Using a standardized immunofluorescent antibody (IFA) technique, we found a significantly higher prevalence of Epstein-Barr virus (EBV) infection and a higher level of serum viral capsid antigen IgG antibody titer in the MS population than in the controls. The MS population had a lower cytomegalovirus (CMV) infection rate and lower CMV complement fixing antibody production than controls. Except for the higher measles infection rate and antibody titer in patients with MS, data on the other viruses did not differ from controls.

Original languageEnglish (US)
Pages (from-to)406-408
Number of pages3
JournalArchives of Neurology
Volume40
Issue number7
DOIs
StatePublished - Jul 1983

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Epstein-Barr Virus Infections
Multiple Sclerosis
Antibodies
Population Control
Viral Antigens
Capsid
Cytomegalovirus Infections
Measles
Demyelinating Diseases
Cytomegalovirus
Antibody Formation
Immunoglobulin G
Infection
Virus
Viruses
Serum
Population

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Epstein-Barr Virus Infection and Antibody Synthesis in Patients With Multiple Sclerosis. / Bray, Patrick F.; Bloomer, Linda C.; Salmon, V. C.; Bagley, Mark H.; Larsen, Paul D.

In: Archives of Neurology, Vol. 40, No. 7, 07.1983, p. 406-408.

Research output: Contribution to journalArticle

Bray, Patrick F. ; Bloomer, Linda C. ; Salmon, V. C. ; Bagley, Mark H. ; Larsen, Paul D. / Epstein-Barr Virus Infection and Antibody Synthesis in Patients With Multiple Sclerosis. In: Archives of Neurology. 1983 ; Vol. 40, No. 7. pp. 406-408.
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