Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt

Josée Audouin, Jacques Diebold, Bharat Nathwani, Elia Ishak, Kenneth MacLennan, Hans Konrad Mueller-Hermelink, James Olen Armitage, Dennis D. Weisenburger

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalJournal of Hematopathology
Volume3
Issue number1
DOIs
StatePublished - Jun 1 2010

Fingerprint

Egypt
Human Herpesvirus 4
Hodgkin Disease
Coloring Agents
Lymphocyte Depletion
Reed-Sternberg Cells
Sclerosis
Developing Countries
In Situ Hybridization
Membrane Proteins
Lymphocytes
RNA
Phenotype

Keywords

  • Classic Hodgkin's lymphoma
  • EBER-1
  • Epstein-Barr virus
  • LMP-1
  • Nodular lymphocyte predominant Hodgkin's lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

Cite this

Audouin, J., Diebold, J., Nathwani, B., Ishak, E., MacLennan, K., Mueller-Hermelink, H. K., ... Weisenburger, D. D. (2010). Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt. Journal of Hematopathology, 3(1), 11-18. https://doi.org/10.1007/s12308-010-0059-3

Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt. / Audouin, Josée; Diebold, Jacques; Nathwani, Bharat; Ishak, Elia; MacLennan, Kenneth; Mueller-Hermelink, Hans Konrad; Armitage, James Olen; Weisenburger, Dennis D.

In: Journal of Hematopathology, Vol. 3, No. 1, 01.06.2010, p. 11-18.

Research output: Contribution to journalArticle

Audouin, J, Diebold, J, Nathwani, B, Ishak, E, MacLennan, K, Mueller-Hermelink, HK, Armitage, JO & Weisenburger, DD 2010, 'Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt', Journal of Hematopathology, vol. 3, no. 1, pp. 11-18. https://doi.org/10.1007/s12308-010-0059-3
Audouin J, Diebold J, Nathwani B, Ishak E, MacLennan K, Mueller-Hermelink HK et al. Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt. Journal of Hematopathology. 2010 Jun 1;3(1):11-18. https://doi.org/10.1007/s12308-010-0059-3
Audouin, Josée ; Diebold, Jacques ; Nathwani, Bharat ; Ishak, Elia ; MacLennan, Kenneth ; Mueller-Hermelink, Hans Konrad ; Armitage, James Olen ; Weisenburger, Dennis D. / Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt. In: Journal of Hematopathology. 2010 ; Vol. 3, No. 1. pp. 11-18.
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