Epstein-Barr nuclear antigen and viral capsidl antigen antibody titers in multiple sclerosis

Paul D. Larsen, Linda C. Bloomer, Patrick F. Bray

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

To characterize the antibody response to the Epstein- Barr virus (EBV) in MS, we studied serum anti-EBV nuclear antigen (anti- EBNA) and anti-EBV capsid antigen (anti-EBVCA) titers. Both titers were assayed in 93 age- and sex-matched pairs of MS patients and controls. Anti- EBVCA titers were measured by indirect immunofluorescence and anti- EBNA titers by anticomplement immunofluorescence. The seropositivity rate of both anti-EBVCA and anti-EBNA in MS patients was 100%, com pared with 84% in controls (p < 0.0001). Both anti-EBVCA and anti- EBNA titers were significantly higher in MS patients than in controls (p < 0.0001). The data suggest that EBV has a significant seroepidemiologic association with MS, but they do not define what role EBV antibodies play in the pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalNeurology
Volume35
Issue number3
StatePublished - Mar 1985

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Nuclear Antigens
Viral Antigens
Epstein-Barr Virus Nuclear Antigens
Human Herpesvirus 4
Multiple Sclerosis
Antibodies
Indirect Fluorescent Antibody Technique
Antibody Formation
Fluorescent Antibody Technique
Serum
Epstein-Barr viral capsid antigen

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Larsen, P. D., Bloomer, L. C., & Bray, P. F. (1985). Epstein-Barr nuclear antigen and viral capsidl antigen antibody titers in multiple sclerosis. Neurology, 35(3), 435-438.

Epstein-Barr nuclear antigen and viral capsidl antigen antibody titers in multiple sclerosis. / Larsen, Paul D.; Bloomer, Linda C.; Bray, Patrick F.

In: Neurology, Vol. 35, No. 3, 03.1985, p. 435-438.

Research output: Contribution to journalArticle

Larsen, PD, Bloomer, LC & Bray, PF 1985, 'Epstein-Barr nuclear antigen and viral capsidl antigen antibody titers in multiple sclerosis', Neurology, vol. 35, no. 3, pp. 435-438.
Larsen, Paul D. ; Bloomer, Linda C. ; Bray, Patrick F. / Epstein-Barr nuclear antigen and viral capsidl antigen antibody titers in multiple sclerosis. In: Neurology. 1985 ; Vol. 35, No. 3. pp. 435-438.
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