Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation

Marcie R. Kritzik, Cory U. Lago, Ayse G. Kayali, Sandrine Arnaud-Dabernat, Guoxun Liu, You Qing Zhang, Hong Hua, Howard S Fox, Nora E Sarvetnick

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.

Original languageEnglish (US)
Pages (from-to)312-321
Number of pages10
JournalEndocrine
Volume37
Issue number2
DOIs
StatePublished - Apr 1 2010

Fingerprint

Cell Differentiation
Epithelium
Epithelial Cells
Regeneration
Pancreas
Growth
Ceruletide
Intestinal Mucosa
Intestines
Gastrointestinal Tract
Membrane Proteins

Keywords

  • CXCR4
  • Intestine
  • Pancreas
  • Regeneration
  • SDF1

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kritzik, M. R., Lago, C. U., Kayali, A. G., Arnaud-Dabernat, S., Liu, G., Zhang, Y. Q., ... Sarvetnick, N. E. (2010). Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation. Endocrine, 37(2), 312-321. https://doi.org/10.1007/s12020-009-9297-5

Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation. / Kritzik, Marcie R.; Lago, Cory U.; Kayali, Ayse G.; Arnaud-Dabernat, Sandrine; Liu, Guoxun; Zhang, You Qing; Hua, Hong; Fox, Howard S; Sarvetnick, Nora E.

In: Endocrine, Vol. 37, No. 2, 01.04.2010, p. 312-321.

Research output: Contribution to journalArticle

Kritzik, MR, Lago, CU, Kayali, AG, Arnaud-Dabernat, S, Liu, G, Zhang, YQ, Hua, H, Fox, HS & Sarvetnick, NE 2010, 'Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation', Endocrine, vol. 37, no. 2, pp. 312-321. https://doi.org/10.1007/s12020-009-9297-5
Kritzik MR, Lago CU, Kayali AG, Arnaud-Dabernat S, Liu G, Zhang YQ et al. Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation. Endocrine. 2010 Apr 1;37(2):312-321. https://doi.org/10.1007/s12020-009-9297-5
Kritzik, Marcie R. ; Lago, Cory U. ; Kayali, Ayse G. ; Arnaud-Dabernat, Sandrine ; Liu, Guoxun ; Zhang, You Qing ; Hua, Hong ; Fox, Howard S ; Sarvetnick, Nora E. / Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation. In: Endocrine. 2010 ; Vol. 37, No. 2. pp. 312-321.
@article{62f9039c2d9448409eb256bd25cfdb0e,
title = "Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation",
abstract = "The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.",
keywords = "CXCR4, Intestine, Pancreas, Regeneration, SDF1",
author = "Kritzik, {Marcie R.} and Lago, {Cory U.} and Kayali, {Ayse G.} and Sandrine Arnaud-Dabernat and Guoxun Liu and Zhang, {You Qing} and Hong Hua and Fox, {Howard S} and Sarvetnick, {Nora E}",
year = "2010",
month = "4",
day = "1",
doi = "10.1007/s12020-009-9297-5",
language = "English (US)",
volume = "37",
pages = "312--321",
journal = "Endocrine",
issn = "1355-008X",
publisher = "Humana Press",
number = "2",

}

TY - JOUR

T1 - Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation

AU - Kritzik, Marcie R.

AU - Lago, Cory U.

AU - Kayali, Ayse G.

AU - Arnaud-Dabernat, Sandrine

AU - Liu, Guoxun

AU - Zhang, You Qing

AU - Hua, Hong

AU - Fox, Howard S

AU - Sarvetnick, Nora E

PY - 2010/4/1

Y1 - 2010/4/1

N2 - The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.

AB - The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.

KW - CXCR4

KW - Intestine

KW - Pancreas

KW - Regeneration

KW - SDF1

UR - http://www.scopus.com/inward/record.url?scp=77952096512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952096512&partnerID=8YFLogxK

U2 - 10.1007/s12020-009-9297-5

DO - 10.1007/s12020-009-9297-5

M3 - Article

C2 - 20960269

AN - SCOPUS:77952096512

VL - 37

SP - 312

EP - 321

JO - Endocrine

JF - Endocrine

SN - 1355-008X

IS - 2

ER -