Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond

Zhiyong Cheng, Louise Zheng, Fabio Almeida

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Environmental factors (e.g., malnutrition and physical inactivity) contribute largely to metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and nonalcoholic fatty liver diseases. The abnormalities in metabolic activity and pathways have been increasingly associated with altered DNA methylation, histone modification and noncoding RNAs, whereas lifestyle interventions targeting diet and physical activity can reverse the epigenetic and metabolic changes. Here we review recent evidence primarily from human studies that links DNA methylation reprogramming to metabolic derangements or improvements, with a focus on cross-tissue (e.g., the liver, skeletal muscle, pancreas, adipose tissue and blood samples) epigenetic markers, mechanistic mediators of the epigenetic reprogramming, and the potential of using epigenetic traits to predict disease risk and intervention response. The challenges in epigenetic studies addressing the mechanisms of metabolic diseases and future directions are also discussed and prospected.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Nutritional Biochemistry
Volume54
DOIs
StatePublished - Apr 2018

Fingerprint

Nutrition Disorders
Epigenomics
Liver
DNA Methylation
Tissue
Histone Code
Untranslated RNA
Nutrition
Medical problems
Histones
Metabolic Diseases
Muscle
Metabolic Networks and Pathways
Blood
Malnutrition
Type 2 Diabetes Mellitus
Adipose Tissue
Life Style
Pancreas
Skeletal Muscle

Keywords

  • DNA methylation
  • Epigenetic marker
  • Intervention
  • Metabolic disorders
  • Reprogramming

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Epigenetic reprogramming in metabolic disorders : nutritional factors and beyond. / Cheng, Zhiyong; Zheng, Louise; Almeida, Fabio.

In: Journal of Nutritional Biochemistry, Vol. 54, 04.2018, p. 1-10.

Research output: Contribution to journalReview article

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