Epigenetic modifications of human placenta associated with preterm birth

a systematic review

Drissa M. Toure, Wael ElRayes, Debora Barnes-Josiah, Teresa Hartman, David L Klinkebiel, Lorena Baccaglini

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Objective: Preterm birth (PTB) is one of the leading causes of neonatal mortality and morbidity around the world. Epigenetic alterations of the human placenta may be involved in the causal chain of adverse pregnancy outcomes specifically PTB. In this systematic review, we investigated whether epigenetic dysregulation of the human placenta is associated with PTB. Methods: We searched MEDLINE and EMBASE and systematically reviewed all relevant studies on epigenetic placental modifications in PTB. Two independent reviewers selected controlled human studies published in any language, evaluated their quality, and graded them using the Newcastle–Ottawa Quality Assessment Scale. We resolved disagreements by consensus with a third reviewer. Results: Eleven observational studies of low to moderate quality met the eligibility criteria out of 60 unique studies. Most studies reported an association between placental epigenetic changes (methylation, mRNA and miRNA) and PTB, although research methods were highly heterogeneous. Conclusions: Studies reported various associations between specific epigenetic findings and PTB, although methodological concerns limited results’ validity. Additional high quality studies are needed to assess the repeatability of these findings. The STROBE guidelines can be used to improve the quality of reporting.

Original languageEnglish (US)
Pages (from-to)530-541
Number of pages12
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume31
Issue number4
DOIs
StatePublished - Feb 16 2018

Fingerprint

Premature Birth
Epigenomics
Placenta
Infant Mortality
Pregnancy Outcome
MicroRNAs
Reproducibility of Results
MEDLINE
Methylation
Observational Studies
Consensus
Language
Guidelines
Morbidity
Messenger RNA
Research

Keywords

  • DNA
  • Epigenetics
  • methylation
  • miRNA
  • preterm birth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Epigenetic modifications of human placenta associated with preterm birth : a systematic review. / Toure, Drissa M.; ElRayes, Wael; Barnes-Josiah, Debora; Hartman, Teresa; Klinkebiel, David L; Baccaglini, Lorena.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 31, No. 4, 16.02.2018, p. 530-541.

Research output: Contribution to journalReview article

@article{e10d96c91fb3480c80bac27cdb05f46a,
title = "Epigenetic modifications of human placenta associated with preterm birth: a systematic review",
abstract = "Objective: Preterm birth (PTB) is one of the leading causes of neonatal mortality and morbidity around the world. Epigenetic alterations of the human placenta may be involved in the causal chain of adverse pregnancy outcomes specifically PTB. In this systematic review, we investigated whether epigenetic dysregulation of the human placenta is associated with PTB. Methods: We searched MEDLINE and EMBASE and systematically reviewed all relevant studies on epigenetic placental modifications in PTB. Two independent reviewers selected controlled human studies published in any language, evaluated their quality, and graded them using the Newcastle–Ottawa Quality Assessment Scale. We resolved disagreements by consensus with a third reviewer. Results: Eleven observational studies of low to moderate quality met the eligibility criteria out of 60 unique studies. Most studies reported an association between placental epigenetic changes (methylation, mRNA and miRNA) and PTB, although research methods were highly heterogeneous. Conclusions: Studies reported various associations between specific epigenetic findings and PTB, although methodological concerns limited results’ validity. Additional high quality studies are needed to assess the repeatability of these findings. The STROBE guidelines can be used to improve the quality of reporting.",
keywords = "DNA, Epigenetics, methylation, miRNA, preterm birth",
author = "Toure, {Drissa M.} and Wael ElRayes and Debora Barnes-Josiah and Teresa Hartman and Klinkebiel, {David L} and Lorena Baccaglini",
year = "2018",
month = "2",
day = "16",
doi = "10.1080/14767058.2017.1291620",
language = "English (US)",
volume = "31",
pages = "530--541",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Epigenetic modifications of human placenta associated with preterm birth

T2 - a systematic review

AU - Toure, Drissa M.

AU - ElRayes, Wael

AU - Barnes-Josiah, Debora

AU - Hartman, Teresa

AU - Klinkebiel, David L

AU - Baccaglini, Lorena

PY - 2018/2/16

Y1 - 2018/2/16

N2 - Objective: Preterm birth (PTB) is one of the leading causes of neonatal mortality and morbidity around the world. Epigenetic alterations of the human placenta may be involved in the causal chain of adverse pregnancy outcomes specifically PTB. In this systematic review, we investigated whether epigenetic dysregulation of the human placenta is associated with PTB. Methods: We searched MEDLINE and EMBASE and systematically reviewed all relevant studies on epigenetic placental modifications in PTB. Two independent reviewers selected controlled human studies published in any language, evaluated their quality, and graded them using the Newcastle–Ottawa Quality Assessment Scale. We resolved disagreements by consensus with a third reviewer. Results: Eleven observational studies of low to moderate quality met the eligibility criteria out of 60 unique studies. Most studies reported an association between placental epigenetic changes (methylation, mRNA and miRNA) and PTB, although research methods were highly heterogeneous. Conclusions: Studies reported various associations between specific epigenetic findings and PTB, although methodological concerns limited results’ validity. Additional high quality studies are needed to assess the repeatability of these findings. The STROBE guidelines can be used to improve the quality of reporting.

AB - Objective: Preterm birth (PTB) is one of the leading causes of neonatal mortality and morbidity around the world. Epigenetic alterations of the human placenta may be involved in the causal chain of adverse pregnancy outcomes specifically PTB. In this systematic review, we investigated whether epigenetic dysregulation of the human placenta is associated with PTB. Methods: We searched MEDLINE and EMBASE and systematically reviewed all relevant studies on epigenetic placental modifications in PTB. Two independent reviewers selected controlled human studies published in any language, evaluated their quality, and graded them using the Newcastle–Ottawa Quality Assessment Scale. We resolved disagreements by consensus with a third reviewer. Results: Eleven observational studies of low to moderate quality met the eligibility criteria out of 60 unique studies. Most studies reported an association between placental epigenetic changes (methylation, mRNA and miRNA) and PTB, although research methods were highly heterogeneous. Conclusions: Studies reported various associations between specific epigenetic findings and PTB, although methodological concerns limited results’ validity. Additional high quality studies are needed to assess the repeatability of these findings. The STROBE guidelines can be used to improve the quality of reporting.

KW - DNA

KW - Epigenetics

KW - methylation

KW - miRNA

KW - preterm birth

UR - http://www.scopus.com/inward/record.url?scp=85040910293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040910293&partnerID=8YFLogxK

U2 - 10.1080/14767058.2017.1291620

DO - 10.1080/14767058.2017.1291620

M3 - Review article

VL - 31

SP - 530

EP - 541

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 4

ER -