Epigenetic changes in BRCA1-mutated familial breast cancer

Bradley Downs, San Ming Wang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Familialbreast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing genome instability via multiple mechanisms including epigenetic changes. This review summarizes recent progress in studying the correlation between BRCA1 predisposition and epigenetic alterations in BRCA1-type familial breast cancer.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalCancer Genetics
Volume208
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Epigenomics
Germ-Line Mutation
Genomic Instability
Breast Neoplasms
Neoplasms
Familial Breast Cancer

Keywords

  • Autosomal dominant
  • BRCA1
  • Epigenetic alteration
  • Familial breast cancer
  • Germline mutation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Epigenetic changes in BRCA1-mutated familial breast cancer. / Downs, Bradley; Wang, San Ming.

In: Cancer Genetics, Vol. 208, No. 5, 01.05.2015, p. 237-240.

Research output: Contribution to journalArticle

Downs, Bradley ; Wang, San Ming. / Epigenetic changes in BRCA1-mutated familial breast cancer. In: Cancer Genetics. 2015 ; Vol. 208, No. 5. pp. 237-240.
@article{350bc934ed8e4bfb8754689ddde883c0,
title = "Epigenetic changes in BRCA1-mutated familial breast cancer",
abstract = "Familialbreast cancer occurs in about 10{\%} of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing genome instability via multiple mechanisms including epigenetic changes. This review summarizes recent progress in studying the correlation between BRCA1 predisposition and epigenetic alterations in BRCA1-type familial breast cancer.",
keywords = "Autosomal dominant, BRCA1, Epigenetic alteration, Familial breast cancer, Germline mutation",
author = "Bradley Downs and Wang, {San Ming}",
year = "2015",
month = "5",
day = "1",
doi = "10.1016/j.cancergen.2015.02.001",
language = "English (US)",
volume = "208",
pages = "237--240",
journal = "Cancer genetics",
issn = "2210-7762",
publisher = "Elsevier BV",
number = "5",

}

TY - JOUR

T1 - Epigenetic changes in BRCA1-mutated familial breast cancer

AU - Downs, Bradley

AU - Wang, San Ming

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Familialbreast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing genome instability via multiple mechanisms including epigenetic changes. This review summarizes recent progress in studying the correlation between BRCA1 predisposition and epigenetic alterations in BRCA1-type familial breast cancer.

AB - Familialbreast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing genome instability via multiple mechanisms including epigenetic changes. This review summarizes recent progress in studying the correlation between BRCA1 predisposition and epigenetic alterations in BRCA1-type familial breast cancer.

KW - Autosomal dominant

KW - BRCA1

KW - Epigenetic alteration

KW - Familial breast cancer

KW - Germline mutation

UR - http://www.scopus.com/inward/record.url?scp=84930575513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930575513&partnerID=8YFLogxK

U2 - 10.1016/j.cancergen.2015.02.001

DO - 10.1016/j.cancergen.2015.02.001

M3 - Article

C2 - 25800897

AN - SCOPUS:84930575513

VL - 208

SP - 237

EP - 240

JO - Cancer genetics

JF - Cancer genetics

SN - 2210-7762

IS - 5

ER -