Epidermodysplasia verruciformis occurring in a patient with human immunodeficiency virus

A case report

Tricia L. Hultgren, Shashi K. Srinivasan, Dominick J DiMaio

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Epidermodysplasia verruciformis (EV) is an uncommon dermatosis associated with human papillomavirus (HPV) infection in association with defects in cell-mediated immunity. Malignant transformation to squamous cell carcinoma has been associated with lesions caused by HPV-5, HPV-8, and HPV-14. Clinically, the disease may be confused with verruca plana, seborrheic keratosis, and pityriasis versicolor. We present an unusual case of EV occurring in a human immunodeficiency virus (HIV)-positive man and discuss the clinical and histologic findings. Clinically, the patient had 1- to 3-mm hypopigmented smooth macules covering the entire body. Histopatho-logic examination of the skin biopsy results demonstrated enlarged keratinocytes with prominent blue-gray cytoplasm and clumping of keratohyalin granules within the granular layer of the epidermis. Although EV typically is viewed as a disease of childhood, sometimes presenting in patients with a family history of the disease, it rarely may be seen in immunocompromised adults.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalCutis
Volume79
Issue number4
StatePublished - Apr 1 2007

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Epidermodysplasia Verruciformis
HIV
Seborrheic Keratosis
Tinea Versicolor
Warts
Papillomavirus Infections
Temazepam
Keratinocytes
Skin Diseases
Epidermis
Cellular Immunity
Squamous Cell Carcinoma
Cytoplasm
Biopsy
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Epidermodysplasia verruciformis occurring in a patient with human immunodeficiency virus : A case report. / Hultgren, Tricia L.; Srinivasan, Shashi K.; DiMaio, Dominick J.

In: Cutis, Vol. 79, No. 4, 01.04.2007, p. 307-311.

Research output: Contribution to journalArticle

Hultgren, Tricia L. ; Srinivasan, Shashi K. ; DiMaio, Dominick J. / Epidermodysplasia verruciformis occurring in a patient with human immunodeficiency virus : A case report. In: Cutis. 2007 ; Vol. 79, No. 4. pp. 307-311.
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