Epidemiology of the non-Hodgkin's lymphomas: Distributions of the major subtypes differ by geographic locations

J. R. Anderson, James Olen Armitage, D. D. Weisenburger

Research output: Contribution to journalArticle

490 Citations (Scopus)

Abstract

Background: There has been no previous systematic study of the distribution of the major subtypes of non-Hodgkin's lymphoma (NHL) across geographic regions, although there have been isolated reports of such differences. Design: As part of a clinical evaluation of the International Lymphoma Study Group (ILSG) classification of NHL, we classified 1378 NHLs from eight different geographic sites (Omaha, NE, USA; Vancouver, BC, Canada; Capetown, South Africa; London, England; Wurzburg/Gottingen, Germany; Lyon, France; Locarno/Bellinzona, Switzerland; and Hong Kong) using the ILSG classification. Results: Substantial differences were found in the distribution of the major subtypes of NHL across geographic regions (P < 0.0001). A greater percentage of follicular lymphoma was seen in North America, London and Capetown (31% versus 14% at other sites). Peripheral T- cell lymphoma was more common in London, Capetown and Hong Kong (9%) than elsewhere (3%). In Locarno/Bellinzona, higher percentages of mediastinal large B-cell lymphoma (9% versus 2% elsewhere) and mantle cell lymphoma (14% versus 6% elsewhere) were seen. Angiocentric nasal T-/NK-cell lymphoma was only seen in Hong Kong (8%) and Lyon (2%). Conclusions: Our study provides evidence that the distribution of NHL subtypes differs by geographic region. These findings suggest that geographical differences in etiologic or host factors may be responsible for the observed differences in the distribution of cases across NHL subtypes.

Original languageEnglish (US)
Pages (from-to)717-720
Number of pages4
JournalAnnals of Oncology
Volume9
Issue number7
DOIs
StatePublished - Jul 1 1998

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Geographic Locations
Non-Hodgkin's Lymphoma
Epidemiology
Hong Kong
Lymphoma
Peripheral T-Cell Lymphoma
Mantle-Cell Lymphoma
Follicular Lymphoma
T-Cell Lymphoma
B-Cell Lymphoma
North America
South Africa
Switzerland
Nose
Natural Killer Cells
England
France
Canada
Germany

Keywords

  • Epidemiology
  • Geography
  • Histologic subtypes
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Epidemiology of the non-Hodgkin's lymphomas : Distributions of the major subtypes differ by geographic locations. / Anderson, J. R.; Armitage, James Olen; Weisenburger, D. D.

In: Annals of Oncology, Vol. 9, No. 7, 01.07.1998, p. 717-720.

Research output: Contribution to journalArticle

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