Epidemiology and etiology of bladder cancer

Sonny L. Johansson, Samuel Monroe Cohen

Research output: Contribution to journalReview article

213 Citations (Scopus)

Abstract

The incidence of bladder cancer continues to increase, with an estimated 53,000 new cases diagnosed in the United States in 1996-90% of which are transitional cell carcinomas. The male-to-female ratio is 3:1. A number of etiological factors are associated with the development of bladder cancer, but in industrialized countries, cigarette smoking is the most important. Specific chemicals have also been identified as causing bladder cancer, as have a number of occupational exposures to less well-defined specific agents. Treatment with cytostatic drugs, especially cyclophosphamide, is associated with increased risk of bladder cancer, as is treatment with radiotherapy for uterine cancer. In developing countries, especially in the Middle East and parts of Africa, infections with members of the genus Schistosoma are responsible for a high incidence of bladder cancer - 75% of which are squamous cell carcinomas. Arsenic has been indicated as a bladder carcinogen in Argentina, Chile, and Taiwan. The reason for the high incidence of urinary tract cancer in individuals suffering from Balkan nephropathy has yet to be determined. A careful history of patients with bladder cancer is an important and useful process in helping to identify causal factor and, in more than one-half the cases, a known relationship is found. Bladder cancer is a potentially preventable disease, with a significant morbidity and mortality in many parts of the world.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalSeminars in Surgical Oncology
Volume13
Issue number5
DOIs
StatePublished - Sep 1 1997

Fingerprint

Urinary Bladder Neoplasms
Epidemiology
Incidence
Balkan Nephropathy
Urologic Neoplasms
Schistosoma
Eastern Africa
Uterine Neoplasms
Middle East
Transitional Cell Carcinoma
Chile
Argentina
Cytostatic Agents
Arsenic
Occupational Exposure
Taiwan
Developed Countries
Carcinogens
Cyclophosphamide
Developing Countries

Keywords

  • Acetylation
  • Acetyltransferases
  • Adenocarcinoma
  • Bladder neoplasms
  • Carcinogens
  • Cyclophosphamide/adverse effects
  • Epidemiology
  • Etiology
  • Mortality
  • Nitrates
  • Nitrites
  • Nitroso compounds
  • Occupational diseases
  • Radiotherapy/adverse effects
  • Risk factors
  • Schistosomiasis
  • Smok ing
  • Squamous cell carcinoma
  • Transitional cell carcinoma
  • Urinary tract infections

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Epidemiology and etiology of bladder cancer. / Johansson, Sonny L.; Cohen, Samuel Monroe.

In: Seminars in Surgical Oncology, Vol. 13, No. 5, 01.09.1997, p. 291-298.

Research output: Contribution to journalReview article

Johansson, Sonny L. ; Cohen, Samuel Monroe. / Epidemiology and etiology of bladder cancer. In: Seminars in Surgical Oncology. 1997 ; Vol. 13, No. 5. pp. 291-298.
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