Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt

Amr S. Soliman, Chu Wei Hung, Alexander Tsodikov, Ibrahim A. Seifeldin, Mohamed Ramadan, Dina Al-Gamal, Emily L. Schiefelbein, Priyanka Thummalapally, Subhojit Dey, Kadry Ismail

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Hepatocellular carcinoma (HCC) is a major health problem worldwide, including Egypt. In the recent past, HCC has become the second most prevalent cancer among men in Egypt. Since HCC has not been well studied in the rural population of Egypt, this case-control study was conducted to investigate the epidemiologic risk factors of HCC in the predominantly rural region of Gharbiah, Egypt. Methods: A total of 150 cases and 150 controls matched to cases on age (±5 years) and sex were recruited from the Gharbiah Cancer Society and Tanta Cancer Center. Exposure data were collected by an interviewer-administered standardized questionnaire about epidemiologic, occupational, medical and family history of HCC. Conditional logistic regression was utilized to calculate unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI). The effect modification of HCC risk between viral infection and environmental risk factors was also assessed. Results: Being an industrial worker was an independent risk for developing HCC (OR 3.54, 95% CI 1.18, 10.63) after adjusting for viral infection, schistosomiasis and tobacco smoking. High relative risk of HCC was observed among HCV-infected individuals who were farmers (OR 9.60, 95% CI 3.72, 24.76), industrial workers (OR 12.90, 95% CI 4.33, 38.43) or active smokers (OR 5.95, 95% CI 2.20, 16.08). Conclusion: Occupational exposure may play an important role in the development of HCC. Farming, industrial exposures and cigarette smoking may increase the risk of HCC among HCV-seropositive individuals. Future research focusing on mechanisms of occupational exposures among HCV patients in this population is needed.

Original languageEnglish (US)
Pages (from-to)681-690
Number of pages10
JournalHepatology International
Volume4
Issue number4
DOIs
StatePublished - Dec 1 2010

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Epidemiologic Factors
Egypt
Hepatocellular Carcinoma
Odds Ratio
Confidence Intervals
Virus Diseases
Occupational Exposure
Medical History Taking
Benzydamine
Smoking
Neoplasms
Schistosomiasis
Rural Population
Agriculture
Case-Control Studies
Logistic Models

Keywords

  • Egypt
  • Gharbiah
  • Hepatocellular carcinoma
  • Rural

ASJC Scopus subject areas

  • Hepatology

Cite this

Soliman, A. S., Hung, C. W., Tsodikov, A., Seifeldin, I. A., Ramadan, M., Al-Gamal, D., ... Ismail, K. (2010). Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt. Hepatology International, 4(4), 681-690. https://doi.org/10.1007/s12072-010-9187-1

Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt. / Soliman, Amr S.; Hung, Chu Wei; Tsodikov, Alexander; Seifeldin, Ibrahim A.; Ramadan, Mohamed; Al-Gamal, Dina; Schiefelbein, Emily L.; Thummalapally, Priyanka; Dey, Subhojit; Ismail, Kadry.

In: Hepatology International, Vol. 4, No. 4, 01.12.2010, p. 681-690.

Research output: Contribution to journalArticle

Soliman, AS, Hung, CW, Tsodikov, A, Seifeldin, IA, Ramadan, M, Al-Gamal, D, Schiefelbein, EL, Thummalapally, P, Dey, S & Ismail, K 2010, 'Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt', Hepatology International, vol. 4, no. 4, pp. 681-690. https://doi.org/10.1007/s12072-010-9187-1
Soliman AS, Hung CW, Tsodikov A, Seifeldin IA, Ramadan M, Al-Gamal D et al. Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt. Hepatology International. 2010 Dec 1;4(4):681-690. https://doi.org/10.1007/s12072-010-9187-1
Soliman, Amr S. ; Hung, Chu Wei ; Tsodikov, Alexander ; Seifeldin, Ibrahim A. ; Ramadan, Mohamed ; Al-Gamal, Dina ; Schiefelbein, Emily L. ; Thummalapally, Priyanka ; Dey, Subhojit ; Ismail, Kadry. / Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt. In: Hepatology International. 2010 ; Vol. 4, No. 4. pp. 681-690.
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title = "Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt",
abstract = "Background: Hepatocellular carcinoma (HCC) is a major health problem worldwide, including Egypt. In the recent past, HCC has become the second most prevalent cancer among men in Egypt. Since HCC has not been well studied in the rural population of Egypt, this case-control study was conducted to investigate the epidemiologic risk factors of HCC in the predominantly rural region of Gharbiah, Egypt. Methods: A total of 150 cases and 150 controls matched to cases on age (±5 years) and sex were recruited from the Gharbiah Cancer Society and Tanta Cancer Center. Exposure data were collected by an interviewer-administered standardized questionnaire about epidemiologic, occupational, medical and family history of HCC. Conditional logistic regression was utilized to calculate unadjusted and adjusted odds ratios (ORs) and 95{\%} confidence intervals (CI). The effect modification of HCC risk between viral infection and environmental risk factors was also assessed. Results: Being an industrial worker was an independent risk for developing HCC (OR 3.54, 95{\%} CI 1.18, 10.63) after adjusting for viral infection, schistosomiasis and tobacco smoking. High relative risk of HCC was observed among HCV-infected individuals who were farmers (OR 9.60, 95{\%} CI 3.72, 24.76), industrial workers (OR 12.90, 95{\%} CI 4.33, 38.43) or active smokers (OR 5.95, 95{\%} CI 2.20, 16.08). Conclusion: Occupational exposure may play an important role in the development of HCC. Farming, industrial exposures and cigarette smoking may increase the risk of HCC among HCV-seropositive individuals. Future research focusing on mechanisms of occupational exposures among HCV patients in this population is needed.",
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AU - Hung, Chu Wei

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AU - Ramadan, Mohamed

AU - Al-Gamal, Dina

AU - Schiefelbein, Emily L.

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N2 - Background: Hepatocellular carcinoma (HCC) is a major health problem worldwide, including Egypt. In the recent past, HCC has become the second most prevalent cancer among men in Egypt. Since HCC has not been well studied in the rural population of Egypt, this case-control study was conducted to investigate the epidemiologic risk factors of HCC in the predominantly rural region of Gharbiah, Egypt. Methods: A total of 150 cases and 150 controls matched to cases on age (±5 years) and sex were recruited from the Gharbiah Cancer Society and Tanta Cancer Center. Exposure data were collected by an interviewer-administered standardized questionnaire about epidemiologic, occupational, medical and family history of HCC. Conditional logistic regression was utilized to calculate unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI). The effect modification of HCC risk between viral infection and environmental risk factors was also assessed. Results: Being an industrial worker was an independent risk for developing HCC (OR 3.54, 95% CI 1.18, 10.63) after adjusting for viral infection, schistosomiasis and tobacco smoking. High relative risk of HCC was observed among HCV-infected individuals who were farmers (OR 9.60, 95% CI 3.72, 24.76), industrial workers (OR 12.90, 95% CI 4.33, 38.43) or active smokers (OR 5.95, 95% CI 2.20, 16.08). Conclusion: Occupational exposure may play an important role in the development of HCC. Farming, industrial exposures and cigarette smoking may increase the risk of HCC among HCV-seropositive individuals. Future research focusing on mechanisms of occupational exposures among HCV patients in this population is needed.

AB - Background: Hepatocellular carcinoma (HCC) is a major health problem worldwide, including Egypt. In the recent past, HCC has become the second most prevalent cancer among men in Egypt. Since HCC has not been well studied in the rural population of Egypt, this case-control study was conducted to investigate the epidemiologic risk factors of HCC in the predominantly rural region of Gharbiah, Egypt. Methods: A total of 150 cases and 150 controls matched to cases on age (±5 years) and sex were recruited from the Gharbiah Cancer Society and Tanta Cancer Center. Exposure data were collected by an interviewer-administered standardized questionnaire about epidemiologic, occupational, medical and family history of HCC. Conditional logistic regression was utilized to calculate unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI). The effect modification of HCC risk between viral infection and environmental risk factors was also assessed. Results: Being an industrial worker was an independent risk for developing HCC (OR 3.54, 95% CI 1.18, 10.63) after adjusting for viral infection, schistosomiasis and tobacco smoking. High relative risk of HCC was observed among HCV-infected individuals who were farmers (OR 9.60, 95% CI 3.72, 24.76), industrial workers (OR 12.90, 95% CI 4.33, 38.43) or active smokers (OR 5.95, 95% CI 2.20, 16.08). Conclusion: Occupational exposure may play an important role in the development of HCC. Farming, industrial exposures and cigarette smoking may increase the risk of HCC among HCV-seropositive individuals. Future research focusing on mechanisms of occupational exposures among HCV patients in this population is needed.

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