Environmentally responsive nanoparticles from block ionomer complexes

Effects of pH and ionic strength

Sergey V. Solomatin, Tatiana K Bronich, Tom W. Bargar, Adi Eisenberg, Victor A. Kabanov, Alexander V. Kabanov

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Nanoscale size materials, displaying environmentally responsive behavior, are of special interest for various applications, including drug delivery. This work explores the effects of environmental parameters (pH, concentration, and chemical nature of low molecular weight salts) on self-assembly and physicochemical properties of block ionomer complexes (BIC). BIC are synthesized by reacting block ionomer (PEO-b-PMA) and oppositely charged surfactant (hexadecyltrimethylammonium bromide). The resulted BIC form stable aqueous dispersions at any ionomer/surfactant ratio (particle size in the 60-90 nm range). Decrease of the ionization degree of the PMA block upon decrease of pH causes elevation of particle size at pH < 5.5 followed by formation of large aggregates at pH < 4. Increase of pH causes a decrease of the particle size. Addition of low molecular weight salts leads to disintegration of BIC at a specific salt concentration termed the "critical salt concentration" or csc. The csc values strongly depend on the nature of the salt. For cations csc increases in the order K+ ≈ Li+ ≈ Na+ gt; N(CH3)4+. For anions it increases in the order I- > Br- > Cl- > AcO- > F-. Such behavior is explained by the contribution of binding of counterions with PMA segments and surfactant cations. The disintegration process is reversible, as BIC particles reconstitute as the salt concentration decreases.

Original languageEnglish (US)
Pages (from-to)8069-8076
Number of pages8
JournalLangmuir
Volume19
Issue number19
DOIs
StatePublished - Sep 16 2003

Fingerprint

Ionomers
Ionic strength
surfactants
Nanoparticles
nanoparticles
Surface-Active Agents
salts
Surface active agents
disintegration
low molecular weights
self assembly
bromides
delivery
drugs
Salts
Particle size
cations
ionization
causes
Disintegration

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Solomatin, S. V., Bronich, T. K., Bargar, T. W., Eisenberg, A., Kabanov, V. A., & Kabanov, A. V. (2003). Environmentally responsive nanoparticles from block ionomer complexes: Effects of pH and ionic strength. Langmuir, 19(19), 8069-8076. https://doi.org/10.1021/la030015l

Environmentally responsive nanoparticles from block ionomer complexes : Effects of pH and ionic strength. / Solomatin, Sergey V.; Bronich, Tatiana K; Bargar, Tom W.; Eisenberg, Adi; Kabanov, Victor A.; Kabanov, Alexander V.

In: Langmuir, Vol. 19, No. 19, 16.09.2003, p. 8069-8076.

Research output: Contribution to journalArticle

Solomatin, SV, Bronich, TK, Bargar, TW, Eisenberg, A, Kabanov, VA & Kabanov, AV 2003, 'Environmentally responsive nanoparticles from block ionomer complexes: Effects of pH and ionic strength', Langmuir, vol. 19, no. 19, pp. 8069-8076. https://doi.org/10.1021/la030015l
Solomatin, Sergey V. ; Bronich, Tatiana K ; Bargar, Tom W. ; Eisenberg, Adi ; Kabanov, Victor A. ; Kabanov, Alexander V. / Environmentally responsive nanoparticles from block ionomer complexes : Effects of pH and ionic strength. In: Langmuir. 2003 ; Vol. 19, No. 19. pp. 8069-8076.
@article{97fb5a4407194e0f9c70ae7d3b127044,
title = "Environmentally responsive nanoparticles from block ionomer complexes: Effects of pH and ionic strength",
abstract = "Nanoscale size materials, displaying environmentally responsive behavior, are of special interest for various applications, including drug delivery. This work explores the effects of environmental parameters (pH, concentration, and chemical nature of low molecular weight salts) on self-assembly and physicochemical properties of block ionomer complexes (BIC). BIC are synthesized by reacting block ionomer (PEO-b-PMA) and oppositely charged surfactant (hexadecyltrimethylammonium bromide). The resulted BIC form stable aqueous dispersions at any ionomer/surfactant ratio (particle size in the 60-90 nm range). Decrease of the ionization degree of the PMA block upon decrease of pH causes elevation of particle size at pH < 5.5 followed by formation of large aggregates at pH < 4. Increase of pH causes a decrease of the particle size. Addition of low molecular weight salts leads to disintegration of BIC at a specific salt concentration termed the {"}critical salt concentration{"} or csc. The csc values strongly depend on the nature of the salt. For cations csc increases in the order K+ ≈ Li+ ≈ Na+ gt; N(CH3)4+. For anions it increases in the order I- > Br- > Cl- > AcO- > F-. Such behavior is explained by the contribution of binding of counterions with PMA segments and surfactant cations. The disintegration process is reversible, as BIC particles reconstitute as the salt concentration decreases.",
author = "Solomatin, {Sergey V.} and Bronich, {Tatiana K} and Bargar, {Tom W.} and Adi Eisenberg and Kabanov, {Victor A.} and Kabanov, {Alexander V.}",
year = "2003",
month = "9",
day = "16",
doi = "10.1021/la030015l",
language = "English (US)",
volume = "19",
pages = "8069--8076",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "19",

}

TY - JOUR

T1 - Environmentally responsive nanoparticles from block ionomer complexes

T2 - Effects of pH and ionic strength

AU - Solomatin, Sergey V.

AU - Bronich, Tatiana K

AU - Bargar, Tom W.

AU - Eisenberg, Adi

AU - Kabanov, Victor A.

AU - Kabanov, Alexander V.

PY - 2003/9/16

Y1 - 2003/9/16

N2 - Nanoscale size materials, displaying environmentally responsive behavior, are of special interest for various applications, including drug delivery. This work explores the effects of environmental parameters (pH, concentration, and chemical nature of low molecular weight salts) on self-assembly and physicochemical properties of block ionomer complexes (BIC). BIC are synthesized by reacting block ionomer (PEO-b-PMA) and oppositely charged surfactant (hexadecyltrimethylammonium bromide). The resulted BIC form stable aqueous dispersions at any ionomer/surfactant ratio (particle size in the 60-90 nm range). Decrease of the ionization degree of the PMA block upon decrease of pH causes elevation of particle size at pH < 5.5 followed by formation of large aggregates at pH < 4. Increase of pH causes a decrease of the particle size. Addition of low molecular weight salts leads to disintegration of BIC at a specific salt concentration termed the "critical salt concentration" or csc. The csc values strongly depend on the nature of the salt. For cations csc increases in the order K+ ≈ Li+ ≈ Na+ gt; N(CH3)4+. For anions it increases in the order I- > Br- > Cl- > AcO- > F-. Such behavior is explained by the contribution of binding of counterions with PMA segments and surfactant cations. The disintegration process is reversible, as BIC particles reconstitute as the salt concentration decreases.

AB - Nanoscale size materials, displaying environmentally responsive behavior, are of special interest for various applications, including drug delivery. This work explores the effects of environmental parameters (pH, concentration, and chemical nature of low molecular weight salts) on self-assembly and physicochemical properties of block ionomer complexes (BIC). BIC are synthesized by reacting block ionomer (PEO-b-PMA) and oppositely charged surfactant (hexadecyltrimethylammonium bromide). The resulted BIC form stable aqueous dispersions at any ionomer/surfactant ratio (particle size in the 60-90 nm range). Decrease of the ionization degree of the PMA block upon decrease of pH causes elevation of particle size at pH < 5.5 followed by formation of large aggregates at pH < 4. Increase of pH causes a decrease of the particle size. Addition of low molecular weight salts leads to disintegration of BIC at a specific salt concentration termed the "critical salt concentration" or csc. The csc values strongly depend on the nature of the salt. For cations csc increases in the order K+ ≈ Li+ ≈ Na+ gt; N(CH3)4+. For anions it increases in the order I- > Br- > Cl- > AcO- > F-. Such behavior is explained by the contribution of binding of counterions with PMA segments and surfactant cations. The disintegration process is reversible, as BIC particles reconstitute as the salt concentration decreases.

UR - http://www.scopus.com/inward/record.url?scp=0141620174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141620174&partnerID=8YFLogxK

U2 - 10.1021/la030015l

DO - 10.1021/la030015l

M3 - Article

VL - 19

SP - 8069

EP - 8076

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 19

ER -