Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC

Andrew K. Adams, Shelley D Smith, Dongnhu T. Truong, Erik G. Willcutt, Richard K. Olson, John C. DeFries, Bruce F. Pennington, Jeffrey R. Gruen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Eleven loci with prior evidence for association with reading and language phenotypes were sequenced in 96 unrelated subjects with significant impairment in reading performance drawn from the Colorado Learning Disability Research Center collection. Out of 148 total individual missense variants identified, the chromosome 7 genes CCDC136 and FLNC contained 19. In addition, a region corresponding to the well-known DYX2 locus for RD contained 74 missense variants. Both allele sets were filtered for a minor allele frequency ≤0.01 and high Polyphen-2 scores. To determine if observations of these alleles are occurring more frequently in our cases than expected by chance in aggregate, counts from our sample were compared to the number of observations in the European subset of the 1000 Genomes Project using Fisher’s exact test. Significant P values were achieved for both CCDC136/FLNC (P = 0.0098) and the DYX2 locus (P = 0.012). Taken together, this evidence further supports the influence of these regions on reading performance. These results also support the influence of rare variants in reading disability.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalHuman Genetics
DOIs
StateAccepted/In press - Sep 2 2017

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Reading
Genes
Alleles
Chromosomes, Human, Pair 7
Learning Disorders
Gene Frequency
Language
Genome
Phenotype
Research

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Adams, A. K., Smith, S. D., Truong, D. T., Willcutt, E. G., Olson, R. K., DeFries, J. C., ... Gruen, J. R. (Accepted/In press). Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC. Human Genetics, 1-11. https://doi.org/10.1007/s00439-017-1838-z

Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC. / Adams, Andrew K.; Smith, Shelley D; Truong, Dongnhu T.; Willcutt, Erik G.; Olson, Richard K.; DeFries, John C.; Pennington, Bruce F.; Gruen, Jeffrey R.

In: Human Genetics, 02.09.2017, p. 1-11.

Research output: Contribution to journalArticle

Adams, Andrew K. ; Smith, Shelley D ; Truong, Dongnhu T. ; Willcutt, Erik G. ; Olson, Richard K. ; DeFries, John C. ; Pennington, Bruce F. ; Gruen, Jeffrey R. / Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC. In: Human Genetics. 2017 ; pp. 1-11.
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