Enhanced production of farnesol by Candida albicans treated with four azoles

Jacob M. Hornby, Kenneth Nickerson

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.

Original languageEnglish (US)
Pages (from-to)2305-2307
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number6
DOIs
StatePublished - Jun 1 2004

Fingerprint

Farnesol
Azoles
Candida albicans
Clotrimazole
Miconazole
Ketoconazole
Fluconazole
Sterols
Fungi

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Enhanced production of farnesol by Candida albicans treated with four azoles. / Hornby, Jacob M.; Nickerson, Kenneth.

In: Antimicrobial Agents and Chemotherapy, Vol. 48, No. 6, 01.06.2004, p. 2305-2307.

Research output: Contribution to journalArticle

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