Enhanced photostability of ICG in close proximity to gold colloids

Chris D. Geddes, Haishi Cao, Joseph R. Lakowicz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Photobleaching of fluorophores frequently limits their detectability or observation time. We examined Indocyanine green (ICG) which is widely used in medical testing and is highly unstable. We showed that spatial localization of ICG near metallic gold colloids resulted in increased photostability. This suggests the use of fluorophore-metal conjugates in situations adversely affected by photobleaching.

Original languageEnglish (US)
Pages (from-to)2611-2617
Number of pages7
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume59
Issue number11
DOIs
StatePublished - Sep 1 2003

Fingerprint

Gold Colloid
Photobleaching
Indocyanine Green
Fluorophores
Colloids
colloids
proximity
Gold
gold
metals
Metals
Testing

Keywords

  • Fluorescence
  • Gold colloids
  • Indocyanine green
  • Photostability

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Spectroscopy

Cite this

Enhanced photostability of ICG in close proximity to gold colloids. / Geddes, Chris D.; Cao, Haishi; Lakowicz, Joseph R.

In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 59, No. 11, 01.09.2003, p. 2611-2617.

Research output: Contribution to journalArticle

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