Enhanced cue-elicited brain activation in African American compared with Caucasian smokers: An fMRI study

Kolawole S. Okuyemi, Joshua N. Powell, Cary R. Savage, Sandra B. Hall, Nicole Nollen, Laura M. Holsen, F. Joseph McClernon, Jasjit S. Ahluwalia

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Current evidence indicates that, although African Americans (AA) are more likely to attempt to quit smoking than Caucasians (CC) in any given year, success rates are lower for AA. However, factors contributing to these differences are not well known. In order to explore potential factors, this study assessed differences in attention to smoking cues between ethnic groups. Participants underwent morning functional magnetic resonance imaging scanning while viewing images of AA models and CC models who were either smoking (smoking cues) or engaging in everyday activities (neutral cues), interspersed with a fixation baseline period. The study was conducted at the Hoglund Brain Imaging Center of the University of Kansas Medical Center in Kansas City, KS. We studied 17 smokers (eight AA, nine CC) after 12-hour abstinence and 17 non-smokers (eight AA, nine CC) matched by age, gender, years of education, and handedness. The AA and CC smoking groups were also matched for number of cigarettes smoked per day. All results are P < 0.01, corrected for whole brain. There was a strong ethnicity by condition interaction among smokers in several a priori regions of interest. AA smokers showed a greater increase in response to smoking (versus neutral cues) than CC smokers in the medial prefrontal cortex, right lateral orbitofrontal cortex, and bilateral ventrolateral prefrontal cortex. In smoking versus baseline contrasts, additional areas of greater activation were found in AA, including the right amygdala and left caudate nucleus. No significant differences in cue-elicited brain activation were found between AA and CC non-smokers. These preliminary findings demonstrate variation in brain activation in response to smoking cues between AA and CC smokers in structures known to be associated with nicotine addiction. Differences in neural response may reflect fundamental differences in attention to smoking cues, which may in turn contribute to differences in effectiveness of nicotine dependence treatments among ethnic populations.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalAddiction Biology
Volume11
Issue number1
DOIs
StatePublished - Mar 1 2006

Fingerprint

African Americans
Cues
Magnetic Resonance Imaging
Smoking
Brain
Prefrontal Cortex
Tobacco Use Disorder
Functional Laterality
Caudate Nucleus
Amygdala
Nicotine
Ethnic Groups
Neuroimaging
Tobacco Products
Education

Keywords

  • African American
  • Caucasian
  • Cue-reactivity
  • Disparities
  • Functional MRI
  • Nicotine dependents

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

Cite this

Enhanced cue-elicited brain activation in African American compared with Caucasian smokers : An fMRI study. / Okuyemi, Kolawole S.; Powell, Joshua N.; Savage, Cary R.; Hall, Sandra B.; Nollen, Nicole; Holsen, Laura M.; McClernon, F. Joseph; Ahluwalia, Jasjit S.

In: Addiction Biology, Vol. 11, No. 1, 01.03.2006, p. 97-106.

Research output: Contribution to journalArticle

Okuyemi, KS, Powell, JN, Savage, CR, Hall, SB, Nollen, N, Holsen, LM, McClernon, FJ & Ahluwalia, JS 2006, 'Enhanced cue-elicited brain activation in African American compared with Caucasian smokers: An fMRI study', Addiction Biology, vol. 11, no. 1, pp. 97-106. https://doi.org/10.1111/j.1369-1600.2006.00007.x
Okuyemi, Kolawole S. ; Powell, Joshua N. ; Savage, Cary R. ; Hall, Sandra B. ; Nollen, Nicole ; Holsen, Laura M. ; McClernon, F. Joseph ; Ahluwalia, Jasjit S. / Enhanced cue-elicited brain activation in African American compared with Caucasian smokers : An fMRI study. In: Addiction Biology. 2006 ; Vol. 11, No. 1. pp. 97-106.
@article{cc40b75d559d4942a8cb96a19defea8d,
title = "Enhanced cue-elicited brain activation in African American compared with Caucasian smokers: An fMRI study",
abstract = "Current evidence indicates that, although African Americans (AA) are more likely to attempt to quit smoking than Caucasians (CC) in any given year, success rates are lower for AA. However, factors contributing to these differences are not well known. In order to explore potential factors, this study assessed differences in attention to smoking cues between ethnic groups. Participants underwent morning functional magnetic resonance imaging scanning while viewing images of AA models and CC models who were either smoking (smoking cues) or engaging in everyday activities (neutral cues), interspersed with a fixation baseline period. The study was conducted at the Hoglund Brain Imaging Center of the University of Kansas Medical Center in Kansas City, KS. We studied 17 smokers (eight AA, nine CC) after 12-hour abstinence and 17 non-smokers (eight AA, nine CC) matched by age, gender, years of education, and handedness. The AA and CC smoking groups were also matched for number of cigarettes smoked per day. All results are P < 0.01, corrected for whole brain. There was a strong ethnicity by condition interaction among smokers in several a priori regions of interest. AA smokers showed a greater increase in response to smoking (versus neutral cues) than CC smokers in the medial prefrontal cortex, right lateral orbitofrontal cortex, and bilateral ventrolateral prefrontal cortex. In smoking versus baseline contrasts, additional areas of greater activation were found in AA, including the right amygdala and left caudate nucleus. No significant differences in cue-elicited brain activation were found between AA and CC non-smokers. These preliminary findings demonstrate variation in brain activation in response to smoking cues between AA and CC smokers in structures known to be associated with nicotine addiction. Differences in neural response may reflect fundamental differences in attention to smoking cues, which may in turn contribute to differences in effectiveness of nicotine dependence treatments among ethnic populations.",
keywords = "African American, Caucasian, Cue-reactivity, Disparities, Functional MRI, Nicotine dependents",
author = "Okuyemi, {Kolawole S.} and Powell, {Joshua N.} and Savage, {Cary R.} and Hall, {Sandra B.} and Nicole Nollen and Holsen, {Laura M.} and McClernon, {F. Joseph} and Ahluwalia, {Jasjit S.}",
year = "2006",
month = "3",
day = "1",
doi = "10.1111/j.1369-1600.2006.00007.x",
language = "English (US)",
volume = "11",
pages = "97--106",
journal = "Addiction Biology",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Enhanced cue-elicited brain activation in African American compared with Caucasian smokers

T2 - An fMRI study

AU - Okuyemi, Kolawole S.

AU - Powell, Joshua N.

AU - Savage, Cary R.

AU - Hall, Sandra B.

AU - Nollen, Nicole

AU - Holsen, Laura M.

AU - McClernon, F. Joseph

AU - Ahluwalia, Jasjit S.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Current evidence indicates that, although African Americans (AA) are more likely to attempt to quit smoking than Caucasians (CC) in any given year, success rates are lower for AA. However, factors contributing to these differences are not well known. In order to explore potential factors, this study assessed differences in attention to smoking cues between ethnic groups. Participants underwent morning functional magnetic resonance imaging scanning while viewing images of AA models and CC models who were either smoking (smoking cues) or engaging in everyday activities (neutral cues), interspersed with a fixation baseline period. The study was conducted at the Hoglund Brain Imaging Center of the University of Kansas Medical Center in Kansas City, KS. We studied 17 smokers (eight AA, nine CC) after 12-hour abstinence and 17 non-smokers (eight AA, nine CC) matched by age, gender, years of education, and handedness. The AA and CC smoking groups were also matched for number of cigarettes smoked per day. All results are P < 0.01, corrected for whole brain. There was a strong ethnicity by condition interaction among smokers in several a priori regions of interest. AA smokers showed a greater increase in response to smoking (versus neutral cues) than CC smokers in the medial prefrontal cortex, right lateral orbitofrontal cortex, and bilateral ventrolateral prefrontal cortex. In smoking versus baseline contrasts, additional areas of greater activation were found in AA, including the right amygdala and left caudate nucleus. No significant differences in cue-elicited brain activation were found between AA and CC non-smokers. These preliminary findings demonstrate variation in brain activation in response to smoking cues between AA and CC smokers in structures known to be associated with nicotine addiction. Differences in neural response may reflect fundamental differences in attention to smoking cues, which may in turn contribute to differences in effectiveness of nicotine dependence treatments among ethnic populations.

AB - Current evidence indicates that, although African Americans (AA) are more likely to attempt to quit smoking than Caucasians (CC) in any given year, success rates are lower for AA. However, factors contributing to these differences are not well known. In order to explore potential factors, this study assessed differences in attention to smoking cues between ethnic groups. Participants underwent morning functional magnetic resonance imaging scanning while viewing images of AA models and CC models who were either smoking (smoking cues) or engaging in everyday activities (neutral cues), interspersed with a fixation baseline period. The study was conducted at the Hoglund Brain Imaging Center of the University of Kansas Medical Center in Kansas City, KS. We studied 17 smokers (eight AA, nine CC) after 12-hour abstinence and 17 non-smokers (eight AA, nine CC) matched by age, gender, years of education, and handedness. The AA and CC smoking groups were also matched for number of cigarettes smoked per day. All results are P < 0.01, corrected for whole brain. There was a strong ethnicity by condition interaction among smokers in several a priori regions of interest. AA smokers showed a greater increase in response to smoking (versus neutral cues) than CC smokers in the medial prefrontal cortex, right lateral orbitofrontal cortex, and bilateral ventrolateral prefrontal cortex. In smoking versus baseline contrasts, additional areas of greater activation were found in AA, including the right amygdala and left caudate nucleus. No significant differences in cue-elicited brain activation were found between AA and CC non-smokers. These preliminary findings demonstrate variation in brain activation in response to smoking cues between AA and CC smokers in structures known to be associated with nicotine addiction. Differences in neural response may reflect fundamental differences in attention to smoking cues, which may in turn contribute to differences in effectiveness of nicotine dependence treatments among ethnic populations.

KW - African American

KW - Caucasian

KW - Cue-reactivity

KW - Disparities

KW - Functional MRI

KW - Nicotine dependents

UR - http://www.scopus.com/inward/record.url?scp=33750705266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750705266&partnerID=8YFLogxK

U2 - 10.1111/j.1369-1600.2006.00007.x

DO - 10.1111/j.1369-1600.2006.00007.x

M3 - Article

C2 - 16759342

AN - SCOPUS:33750705266

VL - 11

SP - 97

EP - 106

JO - Addiction Biology

JF - Addiction Biology

SN - 1355-6215

IS - 1

ER -