Enhanced cell growth by nanoengineering zirconia to stimulate electrostatic fibronectin activation

A. I. Rubinstein, Renat F Sabirianov, Fereydoon Namavar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We address the enhanced bone growth on designed nanocrystalline zirconia implants as reported by in vivo experiments. In vitro experiments demonstrate that the activation of adhesive proteins on nanoengineered zirconia stimulates cell adhesion and growth as shown by confocal microscopy. Fibrillar fibronectin (FN) forms a matrix assembly on the nanostructured surface in the cell adhesion process. We discuss the importance of FN dimer activation due to its immobilization on the designed nanocrystalline ZrO2 implant fabricated by ion beam assisted deposition. The Monte-Carlo analysis indicates that FN activation on the surface can be promoted by selective electrostatic interactions between negatively charged ZrO2 surface patches and oppositely charged FN domains.

Original languageEnglish (US)
Article number065101
JournalNanotechnology
Volume25
Issue number6
DOIs
StatePublished - Feb 14 2014

Fingerprint

Cell growth
Fibronectins
Zirconia
Electrostatics
Chemical activation
Cell adhesion
Ion beam assisted deposition
Confocal microscopy
Coulomb interactions
Dimers
Adhesives
Bone
Experiments
Proteins
zirconium oxide

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Enhanced cell growth by nanoengineering zirconia to stimulate electrostatic fibronectin activation. / Rubinstein, A. I.; Sabirianov, Renat F; Namavar, Fereydoon.

In: Nanotechnology, Vol. 25, No. 6, 065101, 14.02.2014.

Research output: Contribution to journalArticle

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