Engineering oilseeds for sustainable production of industrial and nutritional feedstocks

solving bottlenecks in fatty acid flux

Edgar B Cahoon, Jay M. Shockey, Charles R. Dietrich, Satinder K. Gidda, Robert T. Mullen, John M. Dyer

Research output: Contribution to journalReview article

147 Citations (Scopus)

Abstract

Oilseeds provide a unique platform for the production of high-value fatty acids that can replace non-sustainable petroleum and oceanic sources of specialty chemicals and aquaculture feed. However, recent efforts to engineer the seeds of crop and model plant species to produce new types of fatty acids, including hydroxy and conjugated fatty acids for industrial uses and long-chain omega-3 polyunsaturated fatty acids for farmed fish feed, have met with only modest success. The collective results from these studies point to metabolic 'bottlenecks' in the engineered plant seeds that substantially limit the efficient or selective flux of unusual fatty acids between different substrate pools and ultimately into storage triacylglycerol. Evidence is emerging that diacylglycerol acyltransferase 2, which catalyzes the final step in triacylglycerol assembly, is an important contributor to the synthesis of unusual fatty acid-containing oils, and is likely to be a key target for future oilseed metabolic engineering efforts.

Original languageEnglish (US)
Pages (from-to)236-244
Number of pages9
JournalCurrent Opinion in Plant Biology
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2007

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oilseeds
feedstocks
engineering
fatty acids
triacylglycerols
diacylglycerol acyltransferase
aquaculture feeds
hydroxy fatty acids
farmed fish
metabolic engineering
Spermatophytina
engineers
petroleum
omega-3 fatty acids
fish feeds
oils
synthesis
crops
seeds

ASJC Scopus subject areas

  • Plant Science

Cite this

Engineering oilseeds for sustainable production of industrial and nutritional feedstocks : solving bottlenecks in fatty acid flux. / Cahoon, Edgar B; Shockey, Jay M.; Dietrich, Charles R.; Gidda, Satinder K.; Mullen, Robert T.; Dyer, John M.

In: Current Opinion in Plant Biology, Vol. 10, No. 3, 01.06.2007, p. 236-244.

Research output: Contribution to journalReview article

Cahoon, Edgar B ; Shockey, Jay M. ; Dietrich, Charles R. ; Gidda, Satinder K. ; Mullen, Robert T. ; Dyer, John M. / Engineering oilseeds for sustainable production of industrial and nutritional feedstocks : solving bottlenecks in fatty acid flux. In: Current Opinion in Plant Biology. 2007 ; Vol. 10, No. 3. pp. 236-244.
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