Engineered nanostructured coatings for enhanced protein adsorption and cell growth

Fereydoon Namavar, Alexander Rubinstein, Renat F Sabirianov, Geoffrey Milton Thiele, John G Sharp, Utsav Pokharel, Roxanna M. Namavar, Kevin Lloyd Garvin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

We designed and produced pure cubic zirconia (ZrO 2) ceramic 1 coatings by an ion beam assisted deposition (IBAD) with nanostructures comparable to the size of proteins. Our ceramic coatings exhibit high hardness and a zero contact angle with serum. In contrast to hydroxyapatite (HA), nano-engineered zirconia films possess excellent adhesion to all orthopaedic materials. Cell adhesion and proliferation experiments were performed with a bona fide mesenchymal stromal cell line (OMA-AD). Our experimental results indicate that the nano-engineered cubic zirconia is superior in supporting growth, adhesion, and proliferation. Since cell attachment is mediated by adhesive proteins such as fibronectin (FN), to elucidate why cells attach more effectively to our nanostructures, we performed a comparative analysis of adsorption energies of FN fragment using quantum mechanical calculations and Monte Carlo (MC) simulation both on smooth and nanostructured surfaces. We have found that a FN fragment adsorbs significantly stronger on the nanostructured surface than on the smooth surface 2.

Original languageEnglish (US)
Title of host publicationGels and Biomedical Materials
Pages119-125
Number of pages7
DOIs
StatePublished - Aug 20 2012
Event2011 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 28 2011Dec 2 2011

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1418
ISSN (Print)0272-9172

Other

Other2011 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period11/28/1112/2/11

Fingerprint

Cell growth
Fibronectins
zirconium oxides
Zirconia
adhesion
proteins
Proteins
coatings
Adsorption
Coatings
adsorption
Nanostructures
Adhesion
cells
fragments
Ion beam assisted deposition
orthopedics
ceramic coatings
Ceramic coatings
Cell adhesion

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Namavar, F., Rubinstein, A., Sabirianov, R. F., Thiele, G. M., Sharp, J. G., Pokharel, U., ... Garvin, K. L. (2012). Engineered nanostructured coatings for enhanced protein adsorption and cell growth. In Gels and Biomedical Materials (pp. 119-125). (Materials Research Society Symposium Proceedings; Vol. 1418). https://doi.org/10.1557/opl.2012.394

Engineered nanostructured coatings for enhanced protein adsorption and cell growth. / Namavar, Fereydoon; Rubinstein, Alexander; Sabirianov, Renat F; Thiele, Geoffrey Milton; Sharp, John G; Pokharel, Utsav; Namavar, Roxanna M.; Garvin, Kevin Lloyd.

Gels and Biomedical Materials. 2012. p. 119-125 (Materials Research Society Symposium Proceedings; Vol. 1418).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Namavar, F, Rubinstein, A, Sabirianov, RF, Thiele, GM, Sharp, JG, Pokharel, U, Namavar, RM & Garvin, KL 2012, Engineered nanostructured coatings for enhanced protein adsorption and cell growth. in Gels and Biomedical Materials. Materials Research Society Symposium Proceedings, vol. 1418, pp. 119-125, 2011 MRS Fall Meeting, Boston, MA, United States, 11/28/11. https://doi.org/10.1557/opl.2012.394
Namavar F, Rubinstein A, Sabirianov RF, Thiele GM, Sharp JG, Pokharel U et al. Engineered nanostructured coatings for enhanced protein adsorption and cell growth. In Gels and Biomedical Materials. 2012. p. 119-125. (Materials Research Society Symposium Proceedings). https://doi.org/10.1557/opl.2012.394
Namavar, Fereydoon ; Rubinstein, Alexander ; Sabirianov, Renat F ; Thiele, Geoffrey Milton ; Sharp, John G ; Pokharel, Utsav ; Namavar, Roxanna M. ; Garvin, Kevin Lloyd. / Engineered nanostructured coatings for enhanced protein adsorption and cell growth. Gels and Biomedical Materials. 2012. pp. 119-125 (Materials Research Society Symposium Proceedings).
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