Energy is required for maximal adherence of Neisseria gonorrhoeae to phagocytic and nonphagocytic cells

R. D. Weber, Bradley E Britigan, T. Svendsen, M. S. Cohen

Research output: Contribution to journalArticle

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Abstract

The possibility that gonococcal energy might play a role in the interaction of Neisseria gonorrhoeae with both phagocytic and nonphagocytic cells was examined. Respiratory chain inhibitors including KCN and amobarbital resulted in reduction in gonococcal association with human neutrophils. Similar results were seen with HeLa cells and the human promyelocytic (HL-60) cell line. Identical conditions did not affect the opsonin-dependent association of Staphylococcus aureus with the same cell types. New protein synthesis by gonococci did not account for the observed reduction in association. These results suggest that energy is needed for maximal opsonin-independent association of gonococci with mammalian cells.

Original languageEnglish (US)
Pages (from-to)785-790
Number of pages6
JournalInfection and Immunity
Volume57
Issue number3
StatePublished - Jan 1 1989

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Neisseria gonorrhoeae
Phagocytes
Opsonin Proteins
Amobarbital
HL-60 Cells
Electron Transport
HeLa Cells
Staphylococcus aureus
Neutrophils
Cell Line
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Energy is required for maximal adherence of Neisseria gonorrhoeae to phagocytic and nonphagocytic cells. / Weber, R. D.; Britigan, Bradley E; Svendsen, T.; Cohen, M. S.

In: Infection and Immunity, Vol. 57, No. 3, 01.01.1989, p. 785-790.

Research output: Contribution to journalArticle

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