Endothelin receptors, renal effects and blood pressure

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

The endothelin system has emerged as a key player in the renal control of salt and water homeostasis, exerting profound effects on both the renal vasculature and tubular epithelial cells. Recent advances include new actions of endothelins in the glomerulus, an emerging role for the ETA receptor in chronic kidney disease (CKD) progression and in tubular function, and a more detailed understanding of the tubular response to high salt intake. A large body of evidence also implicates dysfunction of the endothelin system in hypertension, particularly salt-sensitive hypertension, although recent data suggests important sex-differences may exist. Finally, clinical trials indicate that antagonists of endothelin receptors hold great promise in treating resistant hypertension and proteinuric renal disease.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalCurrent Opinion in Pharmacology
Volume21
DOIs
StatePublished - Apr 2015

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Endothelin Receptors
Endothelins
Salts
Blood Pressure
Kidney
Hypertension
Renal Hypertension
Chronic Renal Insufficiency
Sex Characteristics
Disease Progression
Homeostasis
Epithelial Cells
Clinical Trials
Water

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Endothelin receptors, renal effects and blood pressure. / Boesen, Erika I.

In: Current Opinion in Pharmacology, Vol. 21, 04.2015, p. 25-34.

Research output: Contribution to journalReview article

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