Endothelial MicroRNAs and atherosclerosis

Xinghui Sun, Nathan Belkin, Mark W. Feinberg

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The vascular endothelium, a thin layer of endothelial cells (ECs) that line the inner surface of blood vessels, is a critical interface between blood and all tissues. EC activation, dysfunction, and vascular inflammation occur when the endothelium is exposed to various insults such as proinflammatory cytokines, oxidative stress, hypertension, hyperglycemia, aging, and shear stress. These insults lead to the pathogenesis of a range of disease states, including atherosclerosis. Several signaling pathways, especially nuclear factor κB mediated signaling, play crucial roles in these pathophysiological processes. Recently, microRNAs (miRNAs) have emerged as important regulators of EC function by fine-tuning gene expression. In this review, we discuss how miRNAs regulate EC function and vascular inflammation in response to a variety of pathophysiologic stimuli. An understanding of the role of miRNAs in EC activation and dysfunction may provide novel targets and therapeutic opportunities for controlling atherosclerosis and other chronic inflammatory disease states.

Original languageEnglish (US)
Article number372
JournalCurrent Atherosclerosis Reports
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2013

Fingerprint

MicroRNAs
Atherosclerosis
Endothelial Cells
Blood Vessels
Inflammation
Vascular Endothelium
Hyperglycemia
Endothelium
Oxidative Stress
Chronic Disease
Cytokines
Hypertension
Gene Expression
Cell Line
Therapeutics

Keywords

  • Atherosclerosis
  • Endothelial activation
  • MiR-181b
  • MicroRNA
  • Nuclear factor κB
  • Vascular inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Endothelial MicroRNAs and atherosclerosis. / Sun, Xinghui; Belkin, Nathan; Feinberg, Mark W.

In: Current Atherosclerosis Reports, Vol. 15, No. 12, 372, 01.12.2013.

Research output: Contribution to journalArticle

Sun, Xinghui ; Belkin, Nathan ; Feinberg, Mark W. / Endothelial MicroRNAs and atherosclerosis. In: Current Atherosclerosis Reports. 2013 ; Vol. 15, No. 12.
@article{e45509e9be77401392bfbdde9bfcaf34,
title = "Endothelial MicroRNAs and atherosclerosis",
abstract = "The vascular endothelium, a thin layer of endothelial cells (ECs) that line the inner surface of blood vessels, is a critical interface between blood and all tissues. EC activation, dysfunction, and vascular inflammation occur when the endothelium is exposed to various insults such as proinflammatory cytokines, oxidative stress, hypertension, hyperglycemia, aging, and shear stress. These insults lead to the pathogenesis of a range of disease states, including atherosclerosis. Several signaling pathways, especially nuclear factor κB mediated signaling, play crucial roles in these pathophysiological processes. Recently, microRNAs (miRNAs) have emerged as important regulators of EC function by fine-tuning gene expression. In this review, we discuss how miRNAs regulate EC function and vascular inflammation in response to a variety of pathophysiologic stimuli. An understanding of the role of miRNAs in EC activation and dysfunction may provide novel targets and therapeutic opportunities for controlling atherosclerosis and other chronic inflammatory disease states.",
keywords = "Atherosclerosis, Endothelial activation, MiR-181b, MicroRNA, Nuclear factor κB, Vascular inflammation",
author = "Xinghui Sun and Nathan Belkin and Feinberg, {Mark W.}",
year = "2013",
month = "12",
day = "1",
doi = "10.1007/s11883-013-0372-2",
language = "English (US)",
volume = "15",
journal = "Current Atherosclerosis Reports",
issn = "1523-3804",
publisher = "Current Medicine Group",
number = "12",

}

TY - JOUR

T1 - Endothelial MicroRNAs and atherosclerosis

AU - Sun, Xinghui

AU - Belkin, Nathan

AU - Feinberg, Mark W.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - The vascular endothelium, a thin layer of endothelial cells (ECs) that line the inner surface of blood vessels, is a critical interface between blood and all tissues. EC activation, dysfunction, and vascular inflammation occur when the endothelium is exposed to various insults such as proinflammatory cytokines, oxidative stress, hypertension, hyperglycemia, aging, and shear stress. These insults lead to the pathogenesis of a range of disease states, including atherosclerosis. Several signaling pathways, especially nuclear factor κB mediated signaling, play crucial roles in these pathophysiological processes. Recently, microRNAs (miRNAs) have emerged as important regulators of EC function by fine-tuning gene expression. In this review, we discuss how miRNAs regulate EC function and vascular inflammation in response to a variety of pathophysiologic stimuli. An understanding of the role of miRNAs in EC activation and dysfunction may provide novel targets and therapeutic opportunities for controlling atherosclerosis and other chronic inflammatory disease states.

AB - The vascular endothelium, a thin layer of endothelial cells (ECs) that line the inner surface of blood vessels, is a critical interface between blood and all tissues. EC activation, dysfunction, and vascular inflammation occur when the endothelium is exposed to various insults such as proinflammatory cytokines, oxidative stress, hypertension, hyperglycemia, aging, and shear stress. These insults lead to the pathogenesis of a range of disease states, including atherosclerosis. Several signaling pathways, especially nuclear factor κB mediated signaling, play crucial roles in these pathophysiological processes. Recently, microRNAs (miRNAs) have emerged as important regulators of EC function by fine-tuning gene expression. In this review, we discuss how miRNAs regulate EC function and vascular inflammation in response to a variety of pathophysiologic stimuli. An understanding of the role of miRNAs in EC activation and dysfunction may provide novel targets and therapeutic opportunities for controlling atherosclerosis and other chronic inflammatory disease states.

KW - Atherosclerosis

KW - Endothelial activation

KW - MiR-181b

KW - MicroRNA

KW - Nuclear factor κB

KW - Vascular inflammation

UR - http://www.scopus.com/inward/record.url?scp=84885981688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885981688&partnerID=8YFLogxK

U2 - 10.1007/s11883-013-0372-2

DO - 10.1007/s11883-013-0372-2

M3 - Article

VL - 15

JO - Current Atherosclerosis Reports

JF - Current Atherosclerosis Reports

SN - 1523-3804

IS - 12

M1 - 372

ER -