Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET)

C. A. Kauffman, Alison Gail Freifeld, D. R. Andes, J. W. Baddley, L. Herwaldt, R. C. Walker, B. D. Alexander, E. J. Anaissie, K. Benedict, J. I. Ito, K. M. Knapp, G. M. Lyon, K. A. Marr, V. A. Morrison, B. J. Park, T. F. Patterson, M. G. Schuster, T. M. Chiller, P. G. Pappas

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background: Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations. Methods: Fifteen institutions belonging to the Transplant-Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006. Results: A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12-month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died. Conclusions: This 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.

Original languageEnglish (US)
Pages (from-to)213-224
Number of pages12
JournalTransplant Infectious Disease
Volume16
Issue number2
DOIs
StatePublished - Jan 1 2014

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Mycoses
Transplants
Infection
Histoplasmosis
Coccidioidomycosis
Blastomycosis
Transplantation
Transplant Recipients
Epidemiology
Tissue Donors
Prospective Studies

Keywords

  • Blastomycosis
  • Coccidioidomycosis
  • Hematopoietic cell transplant
  • Histoplasmosis
  • Solid organ transplant

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET). / Kauffman, C. A.; Freifeld, Alison Gail; Andes, D. R.; Baddley, J. W.; Herwaldt, L.; Walker, R. C.; Alexander, B. D.; Anaissie, E. J.; Benedict, K.; Ito, J. I.; Knapp, K. M.; Lyon, G. M.; Marr, K. A.; Morrison, V. A.; Park, B. J.; Patterson, T. F.; Schuster, M. G.; Chiller, T. M.; Pappas, P. G.

In: Transplant Infectious Disease, Vol. 16, No. 2, 01.01.2014, p. 213-224.

Research output: Contribution to journalArticle

Kauffman, CA, Freifeld, AG, Andes, DR, Baddley, JW, Herwaldt, L, Walker, RC, Alexander, BD, Anaissie, EJ, Benedict, K, Ito, JI, Knapp, KM, Lyon, GM, Marr, KA, Morrison, VA, Park, BJ, Patterson, TF, Schuster, MG, Chiller, TM & Pappas, PG 2014, 'Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET)', Transplant Infectious Disease, vol. 16, no. 2, pp. 213-224. https://doi.org/10.1111/tid.12186
Kauffman, C. A. ; Freifeld, Alison Gail ; Andes, D. R. ; Baddley, J. W. ; Herwaldt, L. ; Walker, R. C. ; Alexander, B. D. ; Anaissie, E. J. ; Benedict, K. ; Ito, J. I. ; Knapp, K. M. ; Lyon, G. M. ; Marr, K. A. ; Morrison, V. A. ; Park, B. J. ; Patterson, T. F. ; Schuster, M. G. ; Chiller, T. M. ; Pappas, P. G. / Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET). In: Transplant Infectious Disease. 2014 ; Vol. 16, No. 2. pp. 213-224.
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title = "Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET)",
abstract = "Background: Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations. Methods: Fifteen institutions belonging to the Transplant-Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006. Results: A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12-month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102{\%}. Occurrence of infection was bimodal; 28 (40{\%}) infections occurred in the first 6 months post transplantation, and 24 (34{\%}) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16{\%}); no HCT recipient died. Conclusions: This 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.",
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T1 - Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET)

AU - Kauffman, C. A.

AU - Freifeld, Alison Gail

AU - Andes, D. R.

AU - Baddley, J. W.

AU - Herwaldt, L.

AU - Walker, R. C.

AU - Alexander, B. D.

AU - Anaissie, E. J.

AU - Benedict, K.

AU - Ito, J. I.

AU - Knapp, K. M.

AU - Lyon, G. M.

AU - Marr, K. A.

AU - Morrison, V. A.

AU - Park, B. J.

AU - Patterson, T. F.

AU - Schuster, M. G.

AU - Chiller, T. M.

AU - Pappas, P. G.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations. Methods: Fifteen institutions belonging to the Transplant-Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006. Results: A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12-month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died. Conclusions: This 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.

AB - Background: Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations. Methods: Fifteen institutions belonging to the Transplant-Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006. Results: A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12-month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died. Conclusions: This 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.

KW - Blastomycosis

KW - Coccidioidomycosis

KW - Hematopoietic cell transplant

KW - Histoplasmosis

KW - Solid organ transplant

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