Enantioselective alkylation of chiral enolates

D. A. Evans, James M Takacs

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Alkylations of chiral amide enolates derived from (ℓ)-prolinol have been shown to yield versatile hydroxy-amides in high diastereomeric purity. Their use in the preparation of optically active carboxylic acids is described.

Original languageEnglish (US)
Pages (from-to)4233-4236
Number of pages4
JournalTetrahedron Letters
Volume21
Issue number44
DOIs
StatePublished - Jan 1 1980

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Alkylation
Amides
Carboxylic Acids
prolinol

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Enantioselective alkylation of chiral enolates. / Evans, D. A.; Takacs, James M.

In: Tetrahedron Letters, Vol. 21, No. 44, 01.01.1980, p. 4233-4236.

Research output: Contribution to journalArticle

Evans, D. A. ; Takacs, James M. / Enantioselective alkylation of chiral enolates. In: Tetrahedron Letters. 1980 ; Vol. 21, No. 44. pp. 4233-4236.
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