Enantiomerically enriched α-vinyl amino acids via lipase-mediated "reverse transesterification"

David B Berkowitz, James A. Pumphrey, Quanrong Shen

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34 Scopus citations

Abstract

Reduction of protected α-vinyl amino acids produces "neopentyl" alcohols that may be enriched in the L-antipode by lipase-mediated acylation with vinyl acetate. Subsequent deacetylation, oxidation and hydrolysis yields enantiomerically enriched L-α-vinyl amino acids.

Original languageEnglish (US)
Pages (from-to)8743-8746
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number47
DOIs
Publication statusPublished - Nov 21 1994

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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