Enantiomeric synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate

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Abstract

Enantiomerically pure 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1 (ME-CPP) is synthesized from 1,2-O-isopropylidene-α-D-xylofuranose with facile phosphorylation in good yield. Subsequently, the synthesized enantiomerically pure 1 can be used as a substrate in IspG assays to identify inhibitors that may be developed into antibacterial drug leads.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalHeterocycles
Volume76
Issue number1
DOIs
Publication statusPublished - Dec 1 2008

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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