Enantiomeric synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Enantiomerically pure 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1 (ME-CPP) is synthesized from 1,2-O-isopropylidene-α-D-xylofuranose with facile phosphorylation in good yield. Subsequently, the synthesized enantiomerically pure 1 can be used as a substrate in IspG assays to identify inhibitors that may be developed into antibacterial drug leads.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalHeterocycles
Volume76
Issue number1
DOIs
StatePublished - Dec 1 2008

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Phosphorylation
Assays
Substrates
Pharmaceutical Preparations
methyl-D-erythritol 2,4-cyclodiphosphate
propylene

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

Enantiomeric synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate. / Narayanasamy, Prabagaran; Crick, Dean C.

In: Heterocycles, Vol. 76, No. 1, 01.12.2008, p. 243-247.

Research output: Contribution to journalArticle

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