Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications

William K K Wu, Guangshun Wang, Seth B. Coffelt, Aline M. Betancourt, Chung W. Lee, Daiming Fan, Kaichun Wu, Jun Yu, Joseph J Y Sung, Chi H. Cho

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 plays a prominent and complex role in carcinogenesis. Although overexpression of LL-37 has been implicated in the development or progression of many human malignancies, including breast, ovarian and lung cancers, LL-37 suppresses tumorigenesis in gastric cancer. These data are beginning to unveil the intricate and contradictory functions of LL-37. The reasons for the tissue-specific function of LL-37 in carcinogenesis remain to be elucidated. Here, we review the relationship between LL-37, its fragments and cancer progression as well as discuss the potential therapeutic implications of targeting this peptide.

Original languageEnglish (US)
Pages (from-to)1741-1747
Number of pages7
JournalInternational Journal of Cancer
Volume127
Issue number8
DOIs
StatePublished - Oct 15 2010

Fingerprint

Carcinogenesis
Neoplasms
Peptides
Adaptive Immunity
Innate Immunity
Ovarian Neoplasms
Stomach Neoplasms
Lung Neoplasms
Leukocytes
Therapeutics
Epithelial Cells
Breast Neoplasms
CAP18 lipopolysaccharide-binding protein

Keywords

  • breast cancer
  • cathelicidin
  • gastric cancer
  • lung cancer
  • ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. / Wu, William K K; Wang, Guangshun; Coffelt, Seth B.; Betancourt, Aline M.; Lee, Chung W.; Fan, Daiming; Wu, Kaichun; Yu, Jun; Sung, Joseph J Y; Cho, Chi H.

In: International Journal of Cancer, Vol. 127, No. 8, 15.10.2010, p. 1741-1747.

Research output: Contribution to journalReview article

Wu, WKK, Wang, G, Coffelt, SB, Betancourt, AM, Lee, CW, Fan, D, Wu, K, Yu, J, Sung, JJY & Cho, CH 2010, 'Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications', International Journal of Cancer, vol. 127, no. 8, pp. 1741-1747. https://doi.org/10.1002/ijc.25489
Wu, William K K ; Wang, Guangshun ; Coffelt, Seth B. ; Betancourt, Aline M. ; Lee, Chung W. ; Fan, Daiming ; Wu, Kaichun ; Yu, Jun ; Sung, Joseph J Y ; Cho, Chi H. / Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. In: International Journal of Cancer. 2010 ; Vol. 127, No. 8. pp. 1741-1747.
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