Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications

William K.K. Wu, Guangshun Wang, Seth B. Coffelt, Aline M. Betancourt, Chung W. Lee, Daiming Fan, Kaichun Wu, Jun Yu, Joseph J.Y. Sung, Chi H. Cho

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 plays a prominent and complex role in carcinogenesis. Although overexpression of LL-37 has been implicated in the development or progression of many human malignancies, including breast, ovarian and lung cancers, LL-37 suppresses tumorigenesis in gastric cancer. These data are beginning to unveil the intricate and contradictory functions of LL-37. The reasons for the tissue-specific function of LL-37 in carcinogenesis remain to be elucidated. Here, we review the relationship between LL-37, its fragments and cancer progression as well as discuss the potential therapeutic implications of targeting this peptide.

Original languageEnglish (US)
Pages (from-to)1741-1747
Number of pages7
JournalInternational Journal of Cancer
Volume127
Issue number8
DOIs
StatePublished - Oct 15 2010

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Keywords

  • breast cancer
  • cathelicidin
  • gastric cancer
  • lung cancer
  • ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Wu, W. K. K., Wang, G., Coffelt, S. B., Betancourt, A. M., Lee, C. W., Fan, D., Wu, K., Yu, J., Sung, J. J. Y., & Cho, C. H. (2010). Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. International Journal of Cancer, 127(8), 1741-1747. https://doi.org/10.1002/ijc.25489