Emerging Roles of Nitric Oxide Synthase in Bacterial Physiology

Elizabeth H. Hutfless, Sujata S. Chaudhari, Vinai C. Thomas

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Nitric oxide (NO) is a potent inhibitor of diverse cellular processes in bacteria. Therefore, it was surprising to discover that several bacterial species, primarily Gram-positive organisms, harboured a gene encoding nitric oxide synthase (NOS). Recent attempts to characterize bacterial NOS (bNOS) have resulted in the discovery of structural features that may allow it to function as a NO dioxygenase and produce nitrate in addition to NO. Consistent with this characterization, investigations into the biological function of bNOS have also emphasized a role for NOS-dependent nitrate and nitrite production in aerobic and microaerobic respiration. In this review, we aim to compare, contrast, and summarize the structure, biochemistry, and biological role of bNOS with mammalian NOS and discuss how recent advances in our understanding of bNOS have enabled efforts at designing inhibitors against it.

Original languageEnglish (US)
Title of host publicationNitric Oxide and Other Small Signalling Molecules
EditorsRobert K. Poole
PublisherAcademic Press
Pages147-191
Number of pages45
ISBN (Print)9780128144138
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Microbial Physiology
Volume72
ISSN (Print)0065-2911

Fingerprint

Bacterial Physiological Phenomena
Nitric Oxide Synthase
Nitrates
Nitric Oxide
Nitrites
Biochemistry
Respiration
Bacteria
Genes

Keywords

  • Bacteria
  • NO
  • Nitrate
  • Nitric oxide synthase
  • Nitrite
  • bNOS

ASJC Scopus subject areas

  • Microbiology
  • Physiology

Cite this

Hutfless, E. H., Chaudhari, S. S., & Thomas, V. C. (2018). Emerging Roles of Nitric Oxide Synthase in Bacterial Physiology. In R. K. Poole (Ed.), Nitric Oxide and Other Small Signalling Molecules (pp. 147-191). (Advances in Microbial Physiology; Vol. 72). Academic Press. https://doi.org/10.1016/bs.ampbs.2018.01.006

Emerging Roles of Nitric Oxide Synthase in Bacterial Physiology. / Hutfless, Elizabeth H.; Chaudhari, Sujata S.; Thomas, Vinai C.

Nitric Oxide and Other Small Signalling Molecules. ed. / Robert K. Poole. Academic Press, 2018. p. 147-191 (Advances in Microbial Physiology; Vol. 72).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hutfless, EH, Chaudhari, SS & Thomas, VC 2018, Emerging Roles of Nitric Oxide Synthase in Bacterial Physiology. in RK Poole (ed.), Nitric Oxide and Other Small Signalling Molecules. Advances in Microbial Physiology, vol. 72, Academic Press, pp. 147-191. https://doi.org/10.1016/bs.ampbs.2018.01.006
Hutfless EH, Chaudhari SS, Thomas VC. Emerging Roles of Nitric Oxide Synthase in Bacterial Physiology. In Poole RK, editor, Nitric Oxide and Other Small Signalling Molecules. Academic Press. 2018. p. 147-191. (Advances in Microbial Physiology). https://doi.org/10.1016/bs.ampbs.2018.01.006
Hutfless, Elizabeth H. ; Chaudhari, Sujata S. ; Thomas, Vinai C. / Emerging Roles of Nitric Oxide Synthase in Bacterial Physiology. Nitric Oxide and Other Small Signalling Molecules. editor / Robert K. Poole. Academic Press, 2018. pp. 147-191 (Advances in Microbial Physiology).
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