Emerging roles of MUC4 in cancer: A novel target for diagnosis and therapy

Ajay P. Singh, Pallavi Chaturvedi, Surinder Kumar Batra

Research output: Contribution to journalReview article

105 Citations (Scopus)

Abstract

The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalCancer Research
Volume67
Issue number2
DOIs
StatePublished - Jan 15 2007

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Neoplasms
Mucins
Pancreatic Neoplasms
Glycoproteins
Therapeutics
Carcinoma
Trastuzumab

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Emerging roles of MUC4 in cancer : A novel target for diagnosis and therapy. / Singh, Ajay P.; Chaturvedi, Pallavi; Batra, Surinder Kumar.

In: Cancer Research, Vol. 67, No. 2, 15.01.2007, p. 433-436.

Research output: Contribution to journalReview article

Singh, Ajay P. ; Chaturvedi, Pallavi ; Batra, Surinder Kumar. / Emerging roles of MUC4 in cancer : A novel target for diagnosis and therapy. In: Cancer Research. 2007 ; Vol. 67, No. 2. pp. 433-436.
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