Emerging role of mucins in epithelial to mesenchymal transition

Moorthy Palanimuthu Ponnusamy, Parthasarathy Seshacharyulu, Imayavaramban Lakshmanan, Arokia P. Vaz, Seema Chugh, Surinder Kumar Batra

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Epithelial to mesenchymal transition (EMT) is an important and complex phenomenon that determines the aggressiveness of cancer cells. The morphological transformation of cancerous cells is accompanied by various cellular processes such as alterations in cell-cell adhesion, cell matrix degradation, down regulation of epithelial marker E-cadherin and upregulation of mesenchymal markers N-cadherin and Vimentin. Besides these markers several other important tumor antigens/mucins are also involved in the EMT process. Mainly high molecular weight glycoproteins such as mucin molecules (MUC1, MUC4 and MUC16) play a major role in the cellular transformation and signaling alteration in EMT process. In addition to these factors, EMT may be an essential process triggering the emergence or expansion of the CSC population, which slowly results in the initiation of tumor at metastatic sites. Furthermore, mucins have been demonstrated to be involved in the EMT process and also in the enrichment of cancer stem cell population. Mucin mediated EMT is very complex since the key components of tumor microenvironment are also regulating mucin molecules. In this review, we have discussed all the aforementioned factors and their mechanistic involvement for EMT process.

Original languageEnglish (US)
Pages (from-to)945-956
Number of pages12
JournalCurrent Cancer Drug Targets
Volume13
Issue number9
DOIs
StatePublished - Jan 1 2013

Fingerprint

Epithelial-Mesenchymal Transition
Mucins
Cadherins
Cell-Matrix Junctions
Tumor Microenvironment
Neoplastic Stem Cells
Neoplasm Antigens
Vimentin
Population
Neoplasms
Glycoproteins
Up-Regulation
Down-Regulation
Molecular Weight

Keywords

  • Cancer stem cells
  • EMT signaling
  • EMT transcription factors
  • MUC1
  • MUC16
  • MUC4
  • Mucins
  • Tumor microenvironment

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Cancer Research

Cite this

Emerging role of mucins in epithelial to mesenchymal transition. / Palanimuthu Ponnusamy, Moorthy; Seshacharyulu, Parthasarathy; Lakshmanan, Imayavaramban; Vaz, Arokia P.; Chugh, Seema; Batra, Surinder Kumar.

In: Current Cancer Drug Targets, Vol. 13, No. 9, 01.01.2013, p. 945-956.

Research output: Contribution to journalReview article

Palanimuthu Ponnusamy, Moorthy ; Seshacharyulu, Parthasarathy ; Lakshmanan, Imayavaramban ; Vaz, Arokia P. ; Chugh, Seema ; Batra, Surinder Kumar. / Emerging role of mucins in epithelial to mesenchymal transition. In: Current Cancer Drug Targets. 2013 ; Vol. 13, No. 9. pp. 945-956.
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