Emerging candidates in breast cancer stem cell maintenance, therapy resistance and relapse

Bhawna Sharma, Rakesh K Singh

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Therapy resistance is a major concern while treating breast cancer. Various mechanisms have been proposed, but so far nothing has been able to effectively address this problem. Accumulating evidences suggest that a subset of cancer cells provides survival benefits to the tumor and are responsible for therapy resistance and relapse of cancer. These so called the cancer stem cells, are known to be regulated by several pathways. Evidences shows that the tumor microenvironment plays a crucial role in maintaining the cancer stem cell pool. Signaling within the tumor is modulated by surrounding cells which secrete signals favoring tumor growth and metastasis. In breast cancer, the cancer stem cells have recently been reported to be influenced by tumor microenvironment via cytokines which act as chemoattractants for leukocytes. This review elucidates the emerging role of chemokine receptor and receptor activator of NFκB (RANK) ligand/RANK signaling pathways in mediating therapy resistance of breast cancer by maintaining the cancer stem cell pool.

Original languageEnglish (US)
Article number36
JournalJournal of Carcinogenesis
Volume10
DOIs
StatePublished - Dec 1 2011

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Neoplastic Stem Cells
Cell- and Tissue-Based Therapy
Maintenance
Breast Neoplasms
Recurrence
Tumor Microenvironment
Neoplasms
RANK Ligand
Chemokine Receptors
Chemotactic Factors
Cell Survival
Leukocytes
Therapeutics
Cytokines
Neoplasm Metastasis
Growth

Keywords

  • Breast cancer stem cells
  • NFkB (RANK) ligand
  • chemokines
  • therapy resistance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Health, Toxicology and Mutagenesis

Cite this

Emerging candidates in breast cancer stem cell maintenance, therapy resistance and relapse. / Sharma, Bhawna; Singh, Rakesh K.

In: Journal of Carcinogenesis, Vol. 10, 36, 01.12.2011.

Research output: Contribution to journalReview article

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