Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials

Murielle Mimeault, Surinder Kumar Batra

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

The in vivo zebrafish models have recently attracted great attention in molecular oncology to investigate multiple genetic alterations associated with the development of human cancers and validate novel anticancer drug targets. Particularly, the transparent zebrafish models can be used as a xenotransplantation system to rapidly assess the tumorigenicity and metastatic behavior of cancer stem and/or progenitor cells and their progenies. Moreover, the zebrafish models have emerged as powerful tools for an in vivo testing of novel anticancer agents and nanomaterials for counteracting tumor formation and metastases and improving the efficacy of current radiation and chemotherapeutic treatments against aggressive, metastatic and lethal cancers.

Original languageEnglish (US)
Pages (from-to)128-140
Number of pages13
JournalDrug Discovery Today
Volume18
Issue number3-4
DOIs
StatePublished - Feb 1 2013

Fingerprint

Nanostructures
Zebrafish
Pharmaceutical Preparations
Neoplasms
Heterologous Transplantation
Neoplastic Stem Cells
Human Development
Antineoplastic Agents
Stem Cells
Radiation
Neoplasm Metastasis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials. / Mimeault, Murielle; Batra, Surinder Kumar.

In: Drug Discovery Today, Vol. 18, No. 3-4, 01.02.2013, p. 128-140.

Research output: Contribution to journalReview article

@article{da0bb1e32fc7470eb22fb7042c2362a4,
title = "Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials",
abstract = "The in vivo zebrafish models have recently attracted great attention in molecular oncology to investigate multiple genetic alterations associated with the development of human cancers and validate novel anticancer drug targets. Particularly, the transparent zebrafish models can be used as a xenotransplantation system to rapidly assess the tumorigenicity and metastatic behavior of cancer stem and/or progenitor cells and their progenies. Moreover, the zebrafish models have emerged as powerful tools for an in vivo testing of novel anticancer agents and nanomaterials for counteracting tumor formation and metastases and improving the efficacy of current radiation and chemotherapeutic treatments against aggressive, metastatic and lethal cancers.",
author = "Murielle Mimeault and Batra, {Surinder Kumar}",
year = "2013",
month = "2",
day = "1",
doi = "10.1016/j.drudis.2012.08.002",
language = "English (US)",
volume = "18",
pages = "128--140",
journal = "Drug Discovery Today",
issn = "1359-6446",
publisher = "Elsevier Limited",
number = "3-4",

}

TY - JOUR

T1 - Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials

AU - Mimeault, Murielle

AU - Batra, Surinder Kumar

PY - 2013/2/1

Y1 - 2013/2/1

N2 - The in vivo zebrafish models have recently attracted great attention in molecular oncology to investigate multiple genetic alterations associated with the development of human cancers and validate novel anticancer drug targets. Particularly, the transparent zebrafish models can be used as a xenotransplantation system to rapidly assess the tumorigenicity and metastatic behavior of cancer stem and/or progenitor cells and their progenies. Moreover, the zebrafish models have emerged as powerful tools for an in vivo testing of novel anticancer agents and nanomaterials for counteracting tumor formation and metastases and improving the efficacy of current radiation and chemotherapeutic treatments against aggressive, metastatic and lethal cancers.

AB - The in vivo zebrafish models have recently attracted great attention in molecular oncology to investigate multiple genetic alterations associated with the development of human cancers and validate novel anticancer drug targets. Particularly, the transparent zebrafish models can be used as a xenotransplantation system to rapidly assess the tumorigenicity and metastatic behavior of cancer stem and/or progenitor cells and their progenies. Moreover, the zebrafish models have emerged as powerful tools for an in vivo testing of novel anticancer agents and nanomaterials for counteracting tumor formation and metastases and improving the efficacy of current radiation and chemotherapeutic treatments against aggressive, metastatic and lethal cancers.

UR - http://www.scopus.com/inward/record.url?scp=84873091649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873091649&partnerID=8YFLogxK

U2 - 10.1016/j.drudis.2012.08.002

DO - 10.1016/j.drudis.2012.08.002

M3 - Review article

C2 - 22903142

AN - SCOPUS:84873091649

VL - 18

SP - 128

EP - 140

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 3-4

ER -