Emergence of New Delhi metallo-β-lactamase (NDM-5) in Klebsiella quasipneumoniae from neonates in a Nigerian hospital

Lauren M. Brinkac, Richard White, Roshan D'Souza, Kevin Nguyen, Stephen K. Obaro, Derrick E. Fouts

Research output: Contribution to journalArticle

Abstract

Outbreaks of infection occur more often than they are reported in most developing countries, largely due to poor diagnostic services. A Klebsiella species bacteremia outbreak in a newborn unit with high mortality was recently encountered at a location being surveilled for childhood bacteremia. These surveillance efforts offered the opportunity to determine the cause of this neonatal outbreak. In this report, we present the whole-genome sequences of New Delhi metallo-β- lactamase (NDM-5)-containing Klebsiella quasipneumoniae subsp. similipneumoniae bloodstream isolates from a neonatal bacteremia outbreak at a tertiary hospital in Nigeria and as part of the largest collection of K. pneumoniae bloodstream isolates from children in Africa. Comparative analysis of the genetic environment surrounding the NDM-5 genes revealed nearly perfect sequence identity to bla NDM-5 -bearing IncX3-type plasmids from other members of the Enterobacteriaceae.

Original languageEnglish (US)
Article numbere00685-18
JournalmSphere
Volume4
Issue number2
DOIs
StatePublished - Mar 1 2019

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Klebsiella
Disease Outbreaks
Bacteremia
Newborn Infant
Diagnostic Services
Enterobacteriaceae
Nigeria
Tertiary Care Centers
Developing Countries
Pneumonia
Plasmids
Genome
Mortality
Infection
Genes

Keywords

  • Antimicrobial resistance
  • Bacteria
  • Carbapenemase
  • ESBL
  • Enterobacteriaceae
  • Klebsiella
  • Neonate
  • New Delhi metallo-β-lactamase (NDM-5)
  • Nigeria

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Emergence of New Delhi metallo-β-lactamase (NDM-5) in Klebsiella quasipneumoniae from neonates in a Nigerian hospital. / Brinkac, Lauren M.; White, Richard; D'Souza, Roshan; Nguyen, Kevin; Obaro, Stephen K.; Fouts, Derrick E.

In: mSphere, Vol. 4, No. 2, e00685-18, 01.03.2019.

Research output: Contribution to journalArticle

Brinkac, Lauren M. ; White, Richard ; D'Souza, Roshan ; Nguyen, Kevin ; Obaro, Stephen K. ; Fouts, Derrick E. / Emergence of New Delhi metallo-β-lactamase (NDM-5) in Klebsiella quasipneumoniae from neonates in a Nigerian hospital. In: mSphere. 2019 ; Vol. 4, No. 2.
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