Embryonic exposure to maternal testosterone influences age-specific mortality patterns in a captive passerine bird

Hubert Schwabl, Donna Holmes, Rosemary Strasser, Alex Scheuerlein

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Hormones are potent mediators of developmental programming and maternal epigenetic effects. In vertebrates, developmental exposure to maternal androgen hormones has been shown to impact multiple behavioral and physiological traits of progeny, but the possible consequences of this early exposure in terms of aging-related changes in mortality and fitness remain largely unexplored. Avian eggs naturally contain variable doses of maternal hormones - in particular, androgens - which have documented effects on embryo growth and differentiation as well as adult behavior and physiology. Here, we report that injections of a physiological dose of testosterone (T) into yolks of freshly laid eggs of a small, seasonally breeding songbird, the house sparrow (Passer domesticus), increased survivorship in a semi-natural aviary environment. In addition, survival effects of developmental T exposure were sex-dependent, with males generally having a higher risk of death. Separate analyses for young birds in their first year of life (from hatching up to the first reproductive period the following calendar year) and in adulthood (after the first breeding season) showed similar effects. For first-year birds, mortality risk was higher during the winter than during the period after fledging; for adults, mortality risk was higher during the reproductive than the non-reproductive phase (post-breeding molt and winter). T treatment did not affect nestling body mass, but resulted in higher body mass at 3-4 months of age; T and body mass at this age interacted to influence mortality risk. Embryonic exposure to maternal testosterone may result in lower adult mortality by modifying intrinsic physiological processes involved in health or aging over the lifespan of adult birds.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalAGE
Volume34
Issue number1
DOIs
StatePublished - Feb 1 2012

Fingerprint

Maternal Exposure
Birds
Testosterone
Mortality
Breeding
Hormones
Eggs
Androgens
Physiological Phenomena
Sparrows
Songbirds
Epigenomics
Reproduction
Vertebrates
Embryonic Structures
Survival Rate
Mothers
Injections
Health
Growth

Keywords

  • Aging
  • Developmental plasticity
  • Maternal effect
  • Mortality
  • Non-genomic inheritance
  • Prenatal programming
  • Yolk testosterone

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Embryonic exposure to maternal testosterone influences age-specific mortality patterns in a captive passerine bird. / Schwabl, Hubert; Holmes, Donna; Strasser, Rosemary; Scheuerlein, Alex.

In: AGE, Vol. 34, No. 1, 01.02.2012, p. 87-94.

Research output: Contribution to journalArticle

Schwabl, Hubert ; Holmes, Donna ; Strasser, Rosemary ; Scheuerlein, Alex. / Embryonic exposure to maternal testosterone influences age-specific mortality patterns in a captive passerine bird. In: AGE. 2012 ; Vol. 34, No. 1. pp. 87-94.
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