Elucidating the biosynthetic pathway for vibralactone: A pancreatic lipase inhibitor with a fused bicyclic β-lactone

Pei Ji Zhao, Yan Long Yang, Liangchen Du, Ji Kai Liu, Ying Zeng

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Not so simple: Evidence from 13C-labeling studies, metabolite profiling, and cell-free conversion established that the bicycle skeleton of vibralactone is derived from an aryl ring moiety and both shikimate and phenylalanine pathways may contribute. VibPT was found to be potentially involved in vibralactone biosynthesis, as well as an aromatic PTase, which was first characterized in basidiomycete fungi. OPP=pyrophosphate.

Original languageEnglish (US)
Pages (from-to)2298-2302
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number8
DOIs
StatePublished - Feb 18 2013

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Keywords

  • biosynthesis
  • isotopic labeling
  • lactones
  • mass spectrometry
  • natural products

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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