Elevated vitreous concentration of monoclonal immunoglobulin manifesting as schlieren in juvenile rheumatoid arthritis-associated uveitis

Quan Dong Nguyen, R. L. Humphrey, J. P. Dunn, M. S. Humayun

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report the clinical findings and analysis of the immunoglobulin (Ig) composition of the vitreous of a 10-year-old girl with juvenile rheumatoid arthritis-associated uveitis. The vitreous had a schlieren appearance at the time of pars plana lensectomy and vitrectomy. Analysis of the vitreous fluid revealed marked elevation of IgG, IgM, IgA, and albumin levels relative to vitreous fluids from control patients without uveitis. The immunoglobulin coefficients were also elevated for the IgG and IgM classes of immunoglobulins. Immunofixation electrophoresis of the vitreous fluid revealed 2 distinct bands of restricted electrophoretic mobility. These studies suggest that there may be local (intraocular) production of immunoglobulins as an immunologic response in ocular inflammatory diseases such as juvenile rheumatoid arthritis-associated uveitis and that this immunologic response may be monoclonal (possibly biclonal or oligoclonal) in nature.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalArchives of Ophthalmology
Volume119
Issue number2
StatePublished - Feb 22 2001

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Juvenile Arthritis
Uveitis
Immunoglobulins
Immunoglobulin M
Immunoglobulin G
Temazepam
Eye Diseases
Immunoglobulin Isotypes
Vitrectomy
Immunoglobulin A
Electrophoresis
Albumins

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Elevated vitreous concentration of monoclonal immunoglobulin manifesting as schlieren in juvenile rheumatoid arthritis-associated uveitis. / Nguyen, Quan Dong; Humphrey, R. L.; Dunn, J. P.; Humayun, M. S.

In: Archives of Ophthalmology, Vol. 119, No. 2, 22.02.2001, p. 293-296.

Research output: Contribution to journalArticle

Nguyen, Quan Dong ; Humphrey, R. L. ; Dunn, J. P. ; Humayun, M. S. / Elevated vitreous concentration of monoclonal immunoglobulin manifesting as schlieren in juvenile rheumatoid arthritis-associated uveitis. In: Archives of Ophthalmology. 2001 ; Vol. 119, No. 2. pp. 293-296.
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