Electrospun nanofibers for neural tissue engineering

Jingwei Xie, Matthew R. MacEwan, Andrea G. Schwartz, Younan Xia

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

Biodegradable nanofibers produced by electrospinning represent a new class of promising scaffolds to support nerve regeneration. We begin with a brief discussion on the electrospinning of nanofibers and methods for controlling the structure, porosity, and alignment of the electrospun nanofibers. The methods include control of the nanoscale morphology and microscale alignment of the nanofibers, as well as the fabrication of macroscale, three-dimensional tubular structures. We then highlight recent studies that utilize electrospun nanofibers to manipulate biological processes relevant to nervous tissue regeneration, including stem cell differentiation, guidance of neurite extension, and peripheral nerve injury treatments. The main objective of this feature article is to provide valuable insights into methods for investigating the mechanisms of neurite growth on novel nanofibrous scaffolds and optimization of the nanofiber scaffolds and conduits for repairing peripheral nerve injuries.

Original languageEnglish (US)
Pages (from-to)35-44
Number of pages10
JournalNanoscale
Volume2
Issue number1
DOIs
StatePublished - Jan 8 2010

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Nanofibers
Tissue engineering
Scaffolds
Electrospinning
Tissue regeneration
Stem cells
Porosity
Fabrication

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Xie, J., MacEwan, M. R., Schwartz, A. G., & Xia, Y. (2010). Electrospun nanofibers for neural tissue engineering. Nanoscale, 2(1), 35-44. https://doi.org/10.1039/b9nr00243j

Electrospun nanofibers for neural tissue engineering. / Xie, Jingwei; MacEwan, Matthew R.; Schwartz, Andrea G.; Xia, Younan.

In: Nanoscale, Vol. 2, No. 1, 08.01.2010, p. 35-44.

Research output: Contribution to journalArticle

Xie, J, MacEwan, MR, Schwartz, AG & Xia, Y 2010, 'Electrospun nanofibers for neural tissue engineering', Nanoscale, vol. 2, no. 1, pp. 35-44. https://doi.org/10.1039/b9nr00243j
Xie, Jingwei ; MacEwan, Matthew R. ; Schwartz, Andrea G. ; Xia, Younan. / Electrospun nanofibers for neural tissue engineering. In: Nanoscale. 2010 ; Vol. 2, No. 1. pp. 35-44.
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