Electrospinning and morphology of ultrafine poly (D, L-lactide) fibers

Cunhai Dong, Bin Duan, Xiaoyan Yuan, Kangde Yao

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Abstract

Ultrafine poly (D, L-lactide) (PLA) fibers with diameter less than 200 nm produced by electrospinning were studied to obtain tissue restoration resembling extracellular matrix. Scanning electron microscopy was used to observe the fiber morphology. Results showed that the solvent was the critical factor to determine the formation of the electrospun PLA fibers. Compared with acetone, N,N-dimethylformamide (DMF) was a better solvent for PLA to electrospin. Entrance of an organic salt, triethylbenzylammonium chlorate, led to a great increase of the conductivity of PLA/DMF solutions, so that the average fiber diameter of the electrospun PLA fibers decreased dramatically from 500 nm to 100-200 nm. The addition of surfactant, Span-80, did not improve the fiber morphology but formed beaded fiber web.

Original languageEnglish (US)
Pages (from-to)1245-1248
Number of pages4
JournalSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Volume22
Issue number6
StatePublished - Dec 2005

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ASJC Scopus subject areas

  • Biomedical Engineering

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