Electrochemical Detection of Platinum(IV) Prodrug Satraplatin in Serum

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report the design and fabrication of a reagentless and reusable electrochemical sensor for detection of satraplatin (SAT), a platinum(IV) prodrug. The detection strategy is based on the electrocatalytic reaction between the Pt(IV) center of SAT and surface-immobilized methylene blue. We systematically evaluated the effect of passivating diluent chain length on the overall sensor performance. Our results show that the use of a shorter diluent like 2-mercaptoethanol is more advantageous than using a longer and more passivating diluent such as 6-mercapto-1-hexanol. Independent of the use of cyclic voltammetry or chronoamperometry as the sensor interrogation technique, all three sensors, each passivated with a different alkanethiol diluent, have been demonstrated to be sensitive; the limit of detection is in the range of 1-10 M. They are also highly specific and do not respond to Pt(II) drugs such as cisplatin and carboplatin. More importantly, they are selective enough to be employed directly in 50% serum. This sensing strategy has potential applications in clinical pharmacokinetics studies.

Original languageEnglish (US)
Pages (from-to)11092-11097
Number of pages6
JournalAnalytical chemistry
Volume87
Issue number21
DOIs
StatePublished - Nov 3 2015

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Prodrugs
Platinum
Sensors
Electrochemical sensors
Chronoamperometry
Pharmacokinetics
Mercaptoethanol
Methylene Blue
Carboplatin
Chain length
Cisplatin
Cyclic voltammetry
Fabrication
Pharmaceutical Preparations
satraplatin

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Electrochemical Detection of Platinum(IV) Prodrug Satraplatin in Serum. / Wu, Yao; Lai, Rebecca Y.

In: Analytical chemistry, Vol. 87, No. 21, 03.11.2015, p. 11092-11097.

Research output: Contribution to journalArticle

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