Electrical stimulation in isolated rabbit retina

Jeng Shyong Shyu, Mauricio Maia, James D. Weiland, Thomas O'Hearn, Shih Jen Chen, Eyal Margalit, Satoshi Suzuki, Mark S. Humayun

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Experiments were conducted to assess the effect of stimulating electrode parameters (size, position, and waveform shape) on electrically elicited ganglion cell action potentials from isolated rabbit retina. Thirty-eight isolated rabbit retinas were stimulated with bipolar stimulating electrodes (either 125 or 25 μm in diameter) positioned on either the ganglion or the photoreceptor side. Recording electrodes were placed between the optic disc and the stimulating electrodes. Cathodic-first, biphasic, current waveforms of varying pulse durations (0.1, 0.5, 1 ms) were used. For the four conditions tested (125- electrode and 25-μm electrode, ganglion cell, and photoreceptor positions) threshold currents ranged from 6.7 to 23.6 μA, depending on location and pulse duration. With 1-ms pulse duration, no statistically significant difference was seen between threshold currents when either size electrode was used to stimulate either the ganglion cell side or the photoreceptor side. For all groups, the threshold currents using the 1-ms pulse were lower than those using 0.1 ms, but the 0.1-ms pulses used less charge. These experiments provide a number of valuable insights into the relative effects of several stimulation parameters critical to the development of an implanted electronic retinal prosthesis.

Original languageEnglish (US)
Pages (from-to)290-298
Number of pages9
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume14
Issue number3
DOIs
StatePublished - Sep 1 2006

Fingerprint

Electric Stimulation
Retina
Electrodes
Rabbits
Ganglia
Visual Prosthesis
Photoreceptor Cells
Optic Disk
Action Potentials
Optics
Experiments

Keywords

  • Electric stimulation
  • Electrophysiology
  • Prosthesis
  • Rabbit
  • Retina

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Shyu, J. S., Maia, M., Weiland, J. D., O'Hearn, T., Chen, S. J., Margalit, E., ... Humayun, M. S. (2006). Electrical stimulation in isolated rabbit retina. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 14(3), 290-298. https://doi.org/10.1109/TNSRE.2006.881536

Electrical stimulation in isolated rabbit retina. / Shyu, Jeng Shyong; Maia, Mauricio; Weiland, James D.; O'Hearn, Thomas; Chen, Shih Jen; Margalit, Eyal; Suzuki, Satoshi; Humayun, Mark S.

In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 14, No. 3, 01.09.2006, p. 290-298.

Research output: Contribution to journalArticle

Shyu, JS, Maia, M, Weiland, JD, O'Hearn, T, Chen, SJ, Margalit, E, Suzuki, S & Humayun, MS 2006, 'Electrical stimulation in isolated rabbit retina', IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 14, no. 3, pp. 290-298. https://doi.org/10.1109/TNSRE.2006.881536
Shyu, Jeng Shyong ; Maia, Mauricio ; Weiland, James D. ; O'Hearn, Thomas ; Chen, Shih Jen ; Margalit, Eyal ; Suzuki, Satoshi ; Humayun, Mark S. / Electrical stimulation in isolated rabbit retina. In: IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2006 ; Vol. 14, No. 3. pp. 290-298.
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